Results 101 to 110 of about 43,936 (309)

Review of geomechanical problems of accumulation and reduction of mining industry wastes, and ways of their solution [PDF]

, 2018
Purpose. The identification of geomechanical problems of mining industry wastes accumulation and substantiation of the ways for their solution with the possibility of processing the watery technogenic feedstock by fine classification with dewatering ...
Babii, K, Bubnova, O, Chetveryk, M, Moldabaev, S, Shevchenko, O   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Potential effects of environmental change on mining wastes in a hyperarid climate [PDF]

, 2012
Three desert washes were sampled to evaluate the transport of contaminated sediments from abandoned mining sites to downwash environments. The area of concern is an extreme arid climate considered stable and not to pose pathways for contaminated ...
Gillmore, Gavin K., Hooda, Peter S., Sims, Douglas B.   +2 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Bioleaching of Metal-Polluted Mine Tailings: A Comparative Approach Between Ex Situ Slurry-Phase Stirred Reactors Versus In Situ Electrokinetic Percolation

Applied Sciences
This work compares two technologies for the remediation of metal-polluted mine tailings based on lab-scale bioleaching experiments performed in (a) conventional agitated slurry-phase reactors and (b) in situ electrokinetic percolation.
Irene Acosta Hernández, Martín Muñoz Morales, Francisco Jesús Fernández Morales, Luis Rodríguez Romero, José Villaseñor Camacho   +4 more
doaj   +1 more source

Mercury sources and bioavailability in lakes located in the mining district of Chibougamau, eastern Canada [PDF]

, 2011
The presence of Hg in the fish of the lakes from the Cu–Zn–Au mining region of Chibougamau (Canada) represents a serious source of concern for the health of local sports and subsistence fishers. This study focuses on identifying the origin of Hg present
Lucotte, Marc, Petit, Stéphane, Teisserenc, Roman   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effects of Gold Mine Tailings as an Additive on the Tribological Performance of Lubricating Polyurea Grease

Lubricants
Lubricating greases with varying proportions of gold mine tailings or SiO2 as additives were prepared, and their friction and wear performance were evaluated using a four-ball tribometer.
Xiaodong Liu, Heping Wang, Rongshe Wang, Binglong Zhang, Jiqing Wang, Wei Wang, Xihong He   +6 more
doaj   +1 more source

An integrated investigation of the Rio tailings, Panasqueira mine, Centre Portugal [PDF]

, 2009
The risks associated with mine tailings have different nature and, thus, only a multiple approach can investigate and monitor comprehensively the characteristics and evolution of mine tailings impacts on the environment.
Grangeia, Carlos, Matias, M., Silva, E. Ferreira da, Ávila, Paula Freire   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source