Results 71 to 80 of about 2,309 (219)

Molecular–clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas

International Journal of Cancer, Volume 158, Issue 12, Page 3217-3231, 15 June 2026.
What's new? Colorectal neuroendocrine carcinoma (CR‐NEC) is a rare digestive neuroendocrine neoplasm that frequently exhibits an adenocarcinoma component. Nonetheless, the underlying biology of CR‐NEC remains poorly understood. This study examined molecular and clinical features and palliative chemotherapy outcomes of metastatic CR‐NEC, with comparison
Siren Morken, Seppo W. Langer, Geir Olav Hjortland, Anna Sundlöv, Eva Hofsli, Morten Ladekarl, Elizaveta Tabaksblat, Lene Weber Vestermark, Johanna Svensson, Ulrich Knigge, Luís Nunes, Bengt Glimelius, Per Pfeiffer, Kristine Aasebø, Jörg Assmus, Erik Vassella, Inger Marie Bowitz Lothe, Anne Couvelard, Aurel Perren, Stian Knappskog, Halfdan Sorbye   +20 more
wiley   +1 more source

David Spine Concept sistemaren bidezko bizkarreko minen tratamendua [PDF]

, 2017
Ikerketa honetan, bizkarreko minen berrerabiltzerako, indar lan dinamikoan oinarritutako David Spine Concept sistemaren eraginkortasuna aztertu ...
Urrate Antia, Markel
core  

Molecular Analysis of an Intestinal Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) Reveals MLH1 Methylation-driven Microsatellite Instability and a Monoclonal Origin: Diagnostic and Clinical Implications

, 2021
Mixed neuroendocrine/non-neuroendocrine neoplasms (MiNEN) are rare mixed epithelial neoplasms in which a neuroendocrine component is combined with a non-neuroendocrine component.
Sciammarella, Concetta, Chiara Borga, Tsvetkova, Vassilena, Fassan, Matteo, de Manzoni, Giovanni, Mattiolo, Paola, Andrea Mafficini, Maria G. Mastrosimini, Selma Hetoja, Scarpa, Aldo, Hetoja, Selma, Gaetano Paolino, Bencivenga, Maria, Concetta Sciammarella, Paolino, Gaetano, Claudio Luchini, Maria L. Piredda, Matteo Fassan, Piredda, Maria L, Borga, Chiara, Mafficini, Andrea, Aldo Scarpa, Maria Bencivenga, Vassilena Tsvetkova, Giovanni de Manzoni, Luchini, Claudio, Rita T. Lawlor, Lawlor, Rita T, Mastrosimini, Maria G, Paola Mattiolo   +29 more
core   +1 more source

Distinct Adenocarcinoma and Neuroendocrine Carcinoma Components (Suspected Mixed Neuroendocrine‐Non‐Neuroendocrine Neoplasm) Identified by Targeted Biopsy Based on Differences in Endoscopic Findings in an Esophagogastric Junction Carcinoma: A Case Report

DEN Open
Mixed neuroendocrine‐non‐neuroendocrine neoplasm (MiNEN) is a rare, highly malignant tumor comprising both neuroendocrine neoplasm (NEN) and non‐neuroendocrine neoplasm (non‐NEN) components. MiNEN arising at the esophagogastric junction (EGJ) is uncommon,
Kakeru Miyashita, Manabu Takeuchi, Takahiro Taguchi, Seiichi Yoshikawa, Keisuke Morita, Masaru Kumagai, Kazuki Natsui, Yohei Koseki, Natsuki Ishikawa, Erina Kodama   +9 more
doaj   +1 more source

Nano‐Gs‐Protein Peptidomimetika: Rationales Design von Peptiden, die vom C‐Terminus von Gα abgeleitet sind und Schlüsselkomponenten der Gs‐β2AR‐Wechselwirkungen nachahmen

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
G Protein‐gekoppelte Rezeptoren (GPCRs) sind wichtige therapeutische Zielstrukturen. Die Modulation der GPCR‐Aktivität über intrazelluläre Bindungsstellen gewinnt zunehmend an Bedeutung. Ein strukturell und computergestützter Ansatz ermöglichte die Entwicklung kleiner, vom G Protein abgeleiteter Peptidomimetika, die gezielt an die intrazelluläre ...
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Targeted Sequencing of Mixed Neuroendocrine- Non-neuroendocrine Neoplasm of the Gallbladder Suggests a Monoclonal Origin

Philippine Journal of Pathology, 2019
Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the gallbladder is a rare tumor that is defined in the World Health Organization (WHO) 2019 digestive system tumor classification as the presence of a neuroendocrine neoplasm admixed with a non ...
Flora Mae Sta. Ines, Anna Louise Anceno, Rachelle Arah Salamat, Narciso Navarro Jr., Glenda Lyn Pua, Jose Jasper Andal, Daphne Ang   +6 more
doaj   +1 more source

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Polyfluoralkylierte zellpenetrierende Peptid‐Additive verbessern die intrazelluläre Proteinaufnahme durch eine anhaltende und monomere Lipidinteraktion

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
Wir berichten, dass nicht‐zytotoxische, polyfluoralkylierte zellpenetrierende Peptide (CPPs) als CPP‐Additive die intrazelluläre Proteinaufnahme signifikant verbessern, indem sie die Membranverweildauer der CPP‐Additive erhöhen. Durch die Kombination von biophysikalischen Experimenten und Molekulardynamiksimulationen zeigen wir zudem, dass die ...
Sarah Hansen, Hana Zupan, Ferhat Mutlu, Jan Vincent V. Arafiles, Rubén Cruz, Palina Dubatouka, Kenichi Ataka, Martin Lehmann, Bettina G. Keller, Joachim Heberle, Christian P. R. Hackenberger   +10 more
wiley   +1 more source

Beware of drug interactions treating iatrogenic mycobacterium bovis endocarditis from intravesical bcg instillation

, 2021
We report a case of mechanical mitral valve endocarditis associated with miliary disseminated bacillus Calmette-Guerin (BCG) infection following intravesical instillations for minimally invasive bladder cancer in a 65-year-old man.
Albini D., Da Porto A., Minen G., Sechi L. A., Curri F., Casarsa V.   +5 more
core   +1 more source

Feasibility and Short‐Term Outcomes of an endoCUT‐Based Non‐Ligation Cervical Conization Strategy: A Single‐Center Retrospective Study

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 6, June 2026.
ABSTRACT Aim To evaluate perioperative safety and pathological specimen quality in an endoCUT‐based non‐ligation cervical conization strategy. Methods We retrospectively reviewed consecutive patients who underwent cervical conization for suspected or confirmed cervical intraepithelial neoplasia (CIN) or adenocarcinoma in situ (AIS) at Kawasaki ...
Takuma Yoshimura, Isaaki Tatsuta, Tomohiro Suzuki, Yukari Tsuchino, Nao Wakui, Junko Ishigaki, Takashi Takeda, Seon‐Hye Kim, Kenichi Someya, Takashi Iwata, Wataru Yamagami, Sakura Nakada   +11 more
wiley   +1 more source