Results 31 to 40 of about 397,945 (316)
Mining activities through history at Avala locality [PDF]
Podzemni Radovi, 2016 This paper offers a review of some historical evidence and facts about the existence of mining activities in the area of the mountain Avala. Mining activities at Avala can be traced back to the pre-Antiquity times and, depending on the era and political ...
Crnogorac Luka
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Materials Proceedings, 2021 The closure of surface mines is a complex framework characterized by extended reclamations of post-mining sites towards an environmentally friendly and sustainable land-use system development with beneficial returns to society and the economy.
Philip-Mark Spanidis +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Voyage(s) au bout de la mine chez Émile Zola et Fernando Namora
Carnets, 2020 This article proposes a comparative study between two journey(s) to the depths of the mine, with an analysis of Germinal (1885) by French writer Émile Zola (1840-1902) and Minas de San Francisco (1946) by Portuguese writer Fernando Namora (1919-1989 ...
Odete Jubilado
doaj +1 more source
Resources, 2021 Over the past 10 years, the mining industry of Russia has seen a greater than three-fold decrease in injury rates, thanks to the successful implementation of innovative labor safety technologies.
Semyon Gendler, Elizaveta Prokhorova
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mélanges de la Casa de Velázquez, 2014 To study the urban popular classes is an uphill task. Sources are largely silent, making it difficult to identify them, or even to make more than a passing mention of them.
Soizic Croguennec
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source