Results 51 to 60 of about 2,907,575 (304)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Trefftz Method for Time-Dependent Boiling Heat Transfer Calculations in a Mini-Channel Utilising Various Spatial Orientations of the Flow

Energies
The main objective of this study was to investigate boiling heat transfer during refrigerant flow in a mini-channel heat sink. The test section consisted of multiple parallel mini-channels, each with a depth of 1 mm.
Magdalena Piasecka, Sylwia Hożejowska, Artur Maciąg, Anna Pawińska   +3 more
doaj   +1 more source

Heat Transfer Optimization of Three Sections of Mini-channel with CuO Nanofluid [PDF]

Journal of Applied Fluid Mechanics
Three-dimensional channel designs (rectangular, convergent, and converge-diverge) using distilled water and (CuO) nanofluids as a coolant have been compared numerically and experimentally.
F. H. Ali, Z. H. Saadoon, Q. R. Al-amir, H. K. Hamzah   +3 more
doaj   +1 more source

Experimental Study of Flow Characteristic at Horizontal Mini Channel

International Journal of Innovative Research in Science, Engineering and Technology, 2015
The small or mini channel is widely adopted in compact heat exchanger in particular. In present study, the values of velocity and gas void fraction in two-phase gas-liquid flow in mini-channels were experimentally determined. The depth and width of the rectangular cross-section of the channel were 3 mm x 3 mm and 3 mm x 6 mm.
Othman Ashafai Othman Atpoly, Budi Santoso, Dwi Aries, Ammar Mufrih, Latif Ngudi Wibawanto   +4 more
openaire   +1 more source

Effect of the fluid flow fragmentation on the hydrothermal performance enhancement of a serpentine mini-channel heat sink

, 2021
This paper aims to investigate the effect of fluid flow fragmentation on the hydrothermal performance characteristics of a serpentine mini-channel heat sink (SMCHS) numerically and experimentally.
H. M. Jaffal, Basim Freegah, A. Hussain, Ala Hasan   +3 more
semanticscholar   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Two-phase flow patterns in a square mini-channel [PDF]

Journal of Thermal Science, 2004
This paper presents a new set of experimental data of air-water flow patterns in a channel with a cross-section of 1×1 mm2. The ranges of the gas and liquid superficial velocities are 0.1–10 m/s and 0.2–7 m/s, respectively. Bubble, bubble-slug, slug, and frothy flows are observed.
Jianfu Zhao, Gang Liu, Bin Li
openaire   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source