Results 51 to 60 of about 2,459,490 (237)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
UNA ANALISI PER LE POLITICHE DI COMPETITIVITÀ TERRITORIALE. Riferimenti teorici, tecniche di stima e applicazioni. [PDF]
, 2009 Within the weakness of theoretical framework and lack of common definition of competitiveness, the research aims to propose a useful tool to think and implement territorial development policy.
Mini, Valentina
core
, 2019 Full Python model notebook available at: https://anaconda.org/thegregoryireland/mini-grid_model_notebook_v0-2 ...
Gregory Ireland (7515684)
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Energies, 2021 This paper lays out a methodology that could be used by mini-grid developers to assess the design readiness and future design requirement to accommodate electric cooking (eCook).
Shafiqa Keddar +3 more
doaj +1 more source
Análise histomorfológica e histomorfométrica de mini-implantes para ancoragem ortodôntica imediata e precose [PDF]
, 2005 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde . Programa de Pós-Graduação em Odontologia.O objetivo do presente estudo foi avaliar a taxa de sobrevivência e a resposta óssea de mini-implantes submetidos a forças ...
Freire, José Nilo de Oliveira
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Rancang Bangun Inverter Mini 1.5 Vdc to 220 Vac Untuk Lampu Darurat
Jurnal Teknik, 2020 Used cellphone charger components are used as an alternative to create emergency lights which can later be used by the community when the power source from the grid goes out.
Syahrir Abdussamad
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source