The minichromosome maintenance complex drives esophageal basal zone hyperplasia [PDF]
JCI Insight, 2023 Eosinophilic esophagitis (EoE) is a chronic gastrointestinal disorder characterized by food antigen–driven eosinophilic inflammation and hyperproliferation of esophageal mucosa.
M. Rochman +9 more
semanticscholar +5 more sources
Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma [PDF]
Frontiers in Oncology, 2021 Background Minichromosome maintenance (MCM) is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of MCMs in melanoma still remained unclear.
Wei Han +4 more
semanticscholar +5 more sources
Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase [PDF]
Journal of Bacteriology, 2020 Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and ...
Lori M. Kelman +2 more
semanticscholar +7 more sources
Novel protein contact points among
Cancer Medicine, 2022 Identify protein contact points between TP53 and minichromosome maintenance (MCM) complex proteins 2, 3, and 5 with high resolution allowing for potential novel Cancer drug design.
Stephanie Schaefer‐Ramadan +3 more
semanticscholar +4 more sources
Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling [PDF]
iScience, 2023 Summary: Minichromosome maintenance 6 (MCM6) has been implicated in the progression of various malignant tumors; however, its exact physiological function in kidney diseases remains unclear.
Jing Huang +5 more
semanticscholar +5 more sources
Immunohistochemical expression and evaluation of cyclin D1 and minichromosome maintenance 2 in oral squamous cell carcinoma and verrucous carcinoma [PDF]
J Oral Maxillofac Pathol, 2022 Background: The study of cell proliferation is important for assessing the tumor behavior, prognosis and patient survival of oral carcinomas. As literature search did not reveal sufficient studies of immunohistochemical expression of cyclin D1 and ...
T. R. Menaka +5 more
semanticscholar +4 more sources
A Direct Interaction Between P53-Binding Protein 1 and Minichromosome Maintenance Complex in Hepg2 Cells [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. DNA damage repair in cancer cells is a promising approach for the treatment of cancers.
Yong Chen +4 more
semanticscholar +4 more sources
DNA Induces Conformational Changes in a Recombinant Human Minichromosome Maintenance Complex [PDF]
Journal of Biological Chemistry, 2015 ATP-dependent DNA unwinding activity has been demonstrated for recombinant archaeal homohexameric minichromosome maintenance (MCM) complexes and their yeast heterohexameric counterparts, but in higher eukaryotes such as Drosophila, MCM-associated DNA ...
Emma L. Hesketh +6 more
core +9 more sources
PLoS ONE, 2019 Our current study is to identify clinical significance of minichromosome maintenance (MCM) gene expression in Lung Adenocarcinoma (LUAD) using genome-wide RNA sequencing (RNA-seq) dataset and bioinformatics analysis tools.
Kang Liu +3 more
openalex +3 more sources
OncoTargets and Therapy, 2018 Background Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell
Wei Wu +4 more
openalex +3 more sources