Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling [PDF]
iScience, 2023 Summary: Minichromosome maintenance 6 (MCM6) has been implicated in the progression of various malignant tumors; however, its exact physiological function in kidney diseases remains unclear.
Jing Huang +5 more
doaj +4 more sources
Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets [PDF]
FEBS Open Bio, 2023 Lung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA ...
Kengo Tanigawa +9 more
doaj +3 more sources
The minichromosome maintenance complex drives esophageal basal zone hyperplasia [PDF]
JCI Insight, 2023 Eosinophilic esophagitis (EoE) is a chronic gastrointestinal disorder characterized by food antigen–driven eosinophilic inflammation and hyperproliferation of esophageal mucosa.
Mark Rochman +9 more
doaj +3 more sources
Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma [PDF]
Frontiers in Oncology, 2021 BackgroundMinichromosome maintenance (MCM) is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of MCMs in melanoma still remained unclear.MethodsIn the present ...
Wei Han +8 more
doaj +3 more sources
Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity [PDF]
Communications BiologyAccurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication.
Anoop Kumar Yadav +1 more
doaj +3 more sources
Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response [PDF]
CellsThe DNA replication machinery is highly conserved from bacteria to eukaryotic cells. Faithful DNA replication is vital for cells to transmit accurate genetic information to the next generation. However, both internal and external DNA damages threaten the
Agnes Malysa +2 more
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BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10 [PDF]
Pharmaceuticals, 2021 DNA replication is initiated with the recognition of the starting point of multiple replication forks by the origin recognition complex and activation of the minichromosome maintenance complex 10 (MCM10). Subsequently, DNA helicase, consisting of the MCM
Chiao-Hui Hsieh +6 more
doaj +3 more sources
Novel protein contact points among TP53 and minichromosome maintenance complex proteins 2, 3, and 5 [PDF]
Cancer Medicine, 2022 Objective Identify protein contact points between TP53 and minichromosome maintenance (MCM) complex proteins 2, 3, and 5 with high resolution allowing for potential novel Cancer drug design.
Stephanie Schaefer‐Ramadan +3 more
doaj +3 more sources
Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer [PDF]
BMC Cancer, 2019 Background Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies.
A. Hendricks +11 more
doaj +3 more sources
Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Background Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide, it develops resistance to radiotherapy during treatment, understanding the regulatory mechanisms of radioresistance generation is the urgent need for HCC therapy ...
Qing Yang +9 more
doaj +3 more sources