Results 1 to 10 of about 1,216,334 (137)

Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase

Journal of Bacteriology, 2020
Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and ...
Lori M. Kelman, William B. O’Dell, Zvi Kelman   +2 more
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Novel protein contact points among TP53 and minichromosome maintenance complex proteins 2, 3, and 5 [PDF]

Cancer Medicine, 2022
Identify protein contact points between TP53 and minichromosome maintenance (MCM) complex proteins 2, 3, and 5 with high resolution allowing for potential novel Cancer drug design.
Stephanie Schaefer‐Ramadan, Jovana Aleksic, Nayra M. Al‐Thani, Joel A. Malek   +3 more
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Immunohistochemical expression and evaluation of cyclin D1 and minichromosome maintenance 2 in oral squamous cell carcinoma and verrucous carcinoma

Journal of Oral and Maxillofacial Pathology, 2022
Background: The study of cell proliferation is important for assessing the tumor behavior, prognosis and patient survival of oral carcinomas. As literature search did not reveal sufficient studies of immunohistochemical expression of cyclin D1 and ...
T. R. Menaka, S. Shamala Ravikumar, K Dhivya, N. Thilagavathi, J. Dinakaran, Vinoth Kalaichelvan   +5 more
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Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma

Frontiers in Oncology, 2021
Background Minichromosome maintenance (MCM) is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of MCMs in melanoma still remained unclear.
Wei Han, Yizhu Wu, Xiaoyu Zhao, Zhenhua Gong, Guo‐Liang Shen   +4 more
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A Direct Interaction Between P53-Binding Protein 1 and Minichromosome Maintenance Complex in Hepg2 Cells [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. DNA damage repair in cancer cells is a promising approach for the treatment of cancers.
Yong Chen, Chengyin Weng, Hui Zhang, Jianqun Sun, Yawei Yuan   +4 more
openalex   +2 more sources

Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling [PDF]

iScience, 2023
Jing Huang, Zhifeng Xu, Feng Liu, Anni Song, Hua Su, Chun Zhang   +5 more
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Genome-wide investigation of the clinical significance and prospective molecular mechanism of minichromosome maintenance protein family genes in patients with Lung Adenocarcinoma

PLoS ONE, 2019
Our current study is to identify clinical significance of minichromosome maintenance (MCM) gene expression in Lung Adenocarcinoma (LUAD) using genome-wide RNA sequencing (RNA-seq) dataset and bioinformatics analysis tools.
Kang Liu, Min Kang, Xiwen Liao, Rensheng Wang   +3 more
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DNA Induces Conformational Changes in a Recombinant Human Minichromosome Maintenance Complex [PDF]

, 2015
ATP-dependent DNA unwinding activity has been demonstrated for recombinant archaeal homohexameric minichromosome maintenance (MCM) complexes and their yeast heterohexameric counterparts, but in higher eukaryotes such as Drosophila, MCM-associated DNA ...
Emma L. Hesketh, Richard Parker-Manuel, Yuriy Chaban, Rabab Satti, Dawn Coverley, Elena V. Orlova, J. Chong   +6 more
openalex   +4 more sources

Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma

OncoTargets and Therapy, 2018
Background Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell
Wei Wu, Xianwei Wang, Changting Shan, Yong Li, Fengzhu Li   +4 more
openalex   +3 more sources

The minichromosome maintenance complex drives esophageal basal zone hyperplasia

JCI Insight, 2023
Eosinophilic esophagitis (EoE) is a chronic gastrointestinal disorder characterized by food antigen–driven eosinophilic inflammation and hyperproliferation of esophageal mucosa.
M. Rochman, Yrina Rochman, J. Caldwell, Lydia E Mack, John A. Besse, N. Manes, Sung Hwan Yoon, T. Shoda, A. Nita-lazar, M. Rothenberg   +9 more
semanticscholar   +1 more source