Results 91 to 100 of about 1,224,373 (238)

Identification of a Proliferation Gene Cluster Associated with HPV E6/E7 Expression Level and Viral DNA Load in Invasive Cervical Carcinoma

, 2005
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière, Christophe Rosty, Dafna Tsafrir, Eytan Domany, F Ferlay, François Radvanyi, Ilan Tsafrir, Jean Paul Thiery, Jérôme Couturier, Martine Peter, Michal Sheffer, Nicolas Stransky, Patricia de Crémoux, Rémy Salmon, Thierry Dorval, Xavier Sastre-Garau   +15 more
core   +1 more source

Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumors [PDF]

, 2016
Anal cancer is a rare type of digestive tract disease, which has had a crescent incidence in a number of regions. Carcinomas are most frequently found, with squamous cell carcinoma (SCC) comprising similar to 95% of all anal tumors. The major risk factor
Bidinotto, Lucas Tadeu, França, Alessandra Paulino Santos de, Levi, José Eduardo, Loaiza, Edgar Antonio Alemán, Longatto, Adhemar, Lorenzi, Adriana Tarla, Oliveira, Cristina Mendes de, Reis, R. M., Rosa, Luciana Albina Reis, Scapulatempo-Neto, Cristovam, Veo, Carlos A. R.   +10 more
core   +1 more source

Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

Journal of Cytology, 2017
Aims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears.
Zeynep Tosuner, İknur Türkmen, Sema Arıcı, Cavide Sönmez, Seval Turna, Öykü Onaran   +5 more
doaj   +1 more source

De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications. [PDF]

, 2015
Mammalian artificial chromosomes (MACs) are non-integrating, autonomously replicating natural chromosome-based vectors that may carry a vast amount of genetic material, which in turn enable potentially prolonged, safe, and regulated therapeutic transgene
Katona, Róbert László
core   +1 more source

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

npj Breast Cancer, 2021
Resistance to endocrine therapy in estrogen receptor-positive (ER+) breast cancer is a major clinical problem with poorly understood mechanisms. There is an unmet need for prognostic and predictive biomarkers to allow appropriate therapeutic targeting ...
Sanne Løkkegaard, Daniel Elias, Carla L. Alves, Martin V. Bennetzen, Anne-Vibeke Lænkholm, Martin Bak, Morten F. Gjerstorff, Lene E. Johansen, Henriette Vever, Christina Bjerre, Tove Kirkegaard, Bo Nordenskjöld, Tommy Fornander, Olle Stål, Linda S. Lindström, Laura J. Esserman, Anne E. Lykkesfeldt, Jens S. Andersen, Rikke Leth-Larsen, Henrik J. Ditzel   +19 more
doaj   +1 more source

Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma [PDF]

, 2017
The present study aimed to ascertain the significance of topoisomerase II alpha (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma.
Adhemar Longatto-Filho, Adriana Lorenzi, Allini Mafra, Armando G.F. Melani, Bala, Bean, Brown, Carlos Veo, Cristina Mendes de Oliveira, Cristovam Scapulatempo-Neto, Edgar Antonio Alemán Loaiza, Filho, Filho, Firnhaber, Grulich, José Eduardo Levi, José Humberto T.G. Fregnani, Kreuter, Legarth, Longacre, Luciana Albina Reis Rosa, Machalek, Nielsen, Palefsky, Pinto, Pirog, Roelens, Roldán Urgoiti, Saiki, Salit, Serup-Hansen, Shi, Thomas, Valari, Veo, Walboomers, Walts, Wentzensen, Wong, Zandberg   +39 more
core   +1 more source

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

Annals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji, Christian J. Rampal, Esteban C. Rodríguez, Virginie Petel Légaré, Alexandra Lissouba, Sabrina Semmler, Meijiang Liao, Jay P. Ross, Guy A. Rouleau, Christine Vande Velde, Gary A.B. Armstrong   +10 more
wiley   +1 more source

Comparative transcriptome analysis between original and evolved recombinant lactose-consuming Saccharomyces cerevisiae strains [PDF]

, 2008
The engineering of Saccharomyces cerevisiae strains for lactose utilization has been attempted with the intent of developing high productivity processes for alcoholic fermentation of cheese whey. A recombinant S.
Adams, Bro, Cyert, Dollard, Domingues, Edgar, Guimarães, Kim, Kim, Le Berre, Lin, Otero, Poddar, Roth, Sauer, Siso, Zeyl   +16 more
core   +3 more sources

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage [PDF]

, 1994
The rad2 mutant of Schizosaccharomyces pombe is sensitive to UV irradiation and deficient in the repair of UV damage. In addition, it has a very high degree of chromosome loss and/or nondisjunction.
Al-Harithy, R, Carr, A M, Lehmann, A R, Murray, J M, Sheldrick, K S, Tavassoli, M, Watts, F Z   +6 more
core   +1 more source