Results 91 to 100 of about 1,205,791 (198)

Point Mutations in Centromeric Histone Induce Post-zygotic Incompatibility and Uniparental Inheritance. [PDF]

open access: yes, 2015
The centromeric histone 3 variant (CENH3, aka CENP-A) is essential for the segregation of sister chromatids during mitosis and meiosis. To better define CENH3 functional constraints, we complemented a null allele in Arabidopsis with a variety of mutant ...
Britt, Anne B   +6 more
core   +3 more sources

Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program

open access: yesNew Phytologist, Volume 248, Issue 3, Page 1368-1384, November 2025.
Summary Algal blooms and their demise by viruses drive global‐scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal populations are constantly infected by viruses, resistant subpopulations frequently emerge after the infection.
Talia S. Shaler   +5 more
wiley   +1 more source

Meiotic behavior of small chromosomes in maize [PDF]

open access: yes, 2013
The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine, and then separate at anaphase I. At anaphase II, sister chromatids separate.
Fangpu Han, James A. Birchler
core   +2 more sources

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

open access: yesAdvanced Science, Volume 12, Issue 39, October 20, 2025.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen   +8 more
wiley   +1 more source

Effects of Differential Commercial Husbandry Conditions on the Tasmanian Atlantic Salmon Egg Transcriptome

open access: yesAquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.
ABSTRACT Maternally inherited transcripts are crucial for the developmental competence of salmon embryos. Due to the wide variety of broodstock conditioning approaches used in commercial aquaculture, there is a need to understand how dynamic commercial environments impact the egg transcriptome and subsequent quality.
Xin Zhan   +4 more
wiley   +1 more source

Bioinformatic Analysis of the Expression and Clinical Significance of the DNA Replication Regulator MCM Complex in Bladder Cancer

open access: yesInternational Journal of General Medicine, 2022
Ru Chen,1,2,* Bing Hu,1,* Ming Jiang,1,* Wen Deng,1 Ping Zheng,3 Bin Fu1,4 1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Urology, The ...
Chen R   +5 more
doaj  

Taxonomic revision of the genus Lactarius (Russulales, Basidiomycota) in Korea [PDF]

open access: yes, 2019
The genus Lactarius Pers. (Russulales) is a cosmopolitan group of Basidiomycota that forms ectomycorrhizal relationships primarily with both deciduous and coniferous trees.
Eimes, John   +5 more
core   +1 more source

Targeting c‐Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple‐negative breast cancer

open access: yesClinical and Translational Medicine, Volume 15, Issue 10, October 2025.
1. Ras inhibition (Salirasib) combined with c‐Myc targeting blocks MCM2‐driven DNA replication, inducing cell‐cycle arrest and apoptosis. 2. Dual inhibition remodels the immunosuppressive TME, polarising macrophages to M1 and enhancing PD‐L1 blockade efficacy. 3.
Xiaojie Liang   +7 more
wiley   +1 more source

Epigenetic Regulation of Hepatitis B Virus Covalently Closed Circular DNA: Implications for Epigenetic Therapy against Chronic Hepatitis B [PDF]

open access: yes, 2017
Hepatitis B virus (HBV) infection represents a significant public health burden worldwide. Although current therapeutics manage to control the disease progression, lifelong treatment and surveillance are required because drug resistance develops during ...
Guo, Haitao, Hong, Xupeng, Kim, Elena S.
core   +1 more source

Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 10, October 2025.
Regarding the general picture of heart regeneration therapy, it encompasses exogenous cell therapy, endogenous medications, metabolism, interventions in gene pathways, as well as the therapeutic strategies in the burgeoning interdisciplinary field of medicine and engineering in recent years.
Mingchuan Liu   +9 more
wiley   +1 more source

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