Results 101 to 110 of about 1,205,791 (198)
Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells [PDF]
, 2016 © 2016 the American Physiological Society. Airway remodeling is a hallmark feature of asthma and chronic obstructive pulmonary disease. Clinical studies and animal models have demonstrated increased airway smooth muscle (ASM) mass, and ASM thickness is ...
Deshpande, DA +6 more
core +1 more source
Cancer Science, Volume 116, Issue 10, Page 2699-2711, October 2025.We have uncovered a novel mechanism by which HROB modulates cell proliferation in lung adenocarcinoma. Our findings suggest that HROB recruits ZC3HC1 and mediates its de‐phosphorylation at Ser354, which in turn promotes K27‐linked ubiquitination of CCNB1, leading to its proteasomal degradation.
Zhe Zhang +12 more
wiley +1 more source
SMC5/6-Mediated Transcriptional Regulation of Hepatitis B Virus and Its Therapeutic Potential
VirusesCells have developed various mechanisms to counteract viral infections. In an evolutionary arms race, cells mobilize cellular restriction factors to fight off viruses, targeted by viral factors to facilitate their own replication.
Johannes Bächer +2 more
doaj +1 more source
Contact Dermatitis, Volume 93, Issue 4, Page 316-327, October 2025.The carba mix was studied in a human cell model to better understand human patch reactions to the mix. Our results support that the carba mix can give rise to cocktail effect and that patch testing with separate carba mix sensitisers may thus be more appropriate.
Linda Ljungberg Silic +5 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 9, September 2025.The STAT3 pathway plays a crucial role in lung cancer by regulating cell proliferation, survival, angiogenesis, invasion, and metastasis. CUR and RES have emerged as potential therapeutic agents due to their ability to inhibit the STAT3 pathway, reducing tumor growth, angiogenesis, migration, and invasion.
Mohammad Yasin Zamanian +5 more
wiley +1 more source
Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. [PDF]
PLoS Pathogens, 2010 Modulation of host DNA synthesis is essential for many viruses to establish productive infections and contributes to viral diseases. Human cytomegalovirus (HCMV), a large DNA virus, blocks host DNA synthesis and deregulates cell cycle progression.
Zhikang Qian +4 more
doaj +1 more source
Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]
, 2012 Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core
Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres [PDF]
, 2008 Heterochromatin is defined by distinct posttranslational modifications on histones, such as methylation of histone H3 at lysine 9 (H3K9), which allows heterochromatin protein 1 (HP1)–related chromodomain proteins to bind.
A. L. Pidoux +22 more
core +1 more source
Pediatric Discovery, Volume 3, Issue 3, September 2025.The graphical abstract will illustrate the key findings of our study, highlighting the OPC‐like subpopulations and their role in driving tumorigenic lineage transitions in pediatric high‐grade gliomas. ABSTRACT Pediatric high‐grade gliomas (pHGG) were first defined as a distinct entity in the 2021 fifth edition of the WHO classification of tumors of ...
Tian Tian, Chong Huang, Lusheng Li
wiley +1 more source
Proteomic alterations in early stage cervical cancer [PDF]
, 2018 Laser capture microdissection (LCM) allows the capture of cell types or well-defined structures in tissue. We compared in a semi-quantitative way the proteomes from an equivalent of 8,000 tumor cells from patients with squamous cell cervical cancer (SCC,
Bischoff, Rainer +11 more
core +6 more sources