Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets [PDF]
FEBS Open Bio, 2023 Lung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA ...
K. Tanigawa +9 more
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Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity [PDF]
Communications BiologyAccurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication.
A. K. Yadav, Hana Polasek-Sedlackova
semanticscholar +3 more sources
Expression of minichromosome maintenance genes in renal cell carcinoma [PDF]
Cancer Management and Research, 2017 Hongbin Zhong,1,* Bin Chen,1,* Henrique Neves,2 Jinchun Xing,1 Youxin Ye,1 Ying Lin,1 Guohong Zhuang,3 Shu-Dong Zhang,4 Jiyi Huang,1,5 Hang Fai Kwok2 1Xiang’an Branch, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People’
Zhong HB +9 more
doaj +6 more sources
BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10 [PDF]
Pharmaceuticals, 2021 DNA replication is initiated with the recognition of the starting point of multiple replication forks by the origin recognition complex and activation of the minichromosome maintenance complex 10 (MCM10). Subsequently, DNA helicase, consisting of the MCM
C. Hsieh +6 more
semanticscholar +4 more sources
Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer [PDF]
BMC Cancer, 2019 Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies. In terms of colorectal cancer, the impact of
A. Hendricks +11 more
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Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide, it develops resistance to radiotherapy during treatment, understanding the regulatory mechanisms of radioresistance generation is the urgent need for HCC therapy. qRT-PCR, western
Wei Meng +9 more
semanticscholar +4 more sources
Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma [PDF]
Oncology Reports, 2019 The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well-studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic
Shu Li, Zhou Jiang, Yirun Li, Yang Xu
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Translational Oncology, 2016 BACKGROUND: Small intestinal neuroendocrine neoplasm (SI-NEN) proliferation is quantified by Ki67 measurements which capture G1-G2M phases of the cell cycle.
Simon Schimmack +5 more
doaj +5 more sources
Minichromosome maintenance gene family: potential therapeutic targets and prognostic biomarkers for lung squamous cell carcinoma [PDF]
Aging (Albany NY), 2022 The minichromosome maintenance (MCM) gene family comprises of ten members with key roles in eukaryotic DNA replication and are associated with the occurrence and progression of many tumors.
Xuejie Yang +5 more
semanticscholar +2 more sources
The High Expression of Minichromosome Maintenance Complex Component 5 Is an Adverse Prognostic Factor in Lung Adenocarcinoma [PDF]
Biomed Res Int, 2022 Background Minichromosome maintenance (MCM) genes are crucial for genomic DNA replication and are important biomarkers in tumor biology. In this study, we aimed to identify the diagnostic, therapeutic, and prognostic value of the MCM2–10 genes in ...
M. Sun +5 more
semanticscholar +2 more sources