Frontiers in Bioscience-Landmark, 2023 BACKGROUND Epigenetic modifications, such as transcription, DNA repair, and replication significantly influence tumour development. Aberrant gene expression and modifications can have a crucial impact on the initiation and progression of tumours.
Lulu Wang, Xiaowei Liu
semanticscholar +3 more sources
Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. [PDF]
Mol Clin Oncol, 2021 Minichromosome maintenance (MCM) protein deregulation is associated with tumor formation, progression and malignant transformation. MCM2 is frequently expressed during premalignant lung cell proliferation and is a sensitive marker for the early detection
Hiroki Sakai +12 more
semanticscholar +2 more sources
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer [PDF]
BMC Cancer, 2021 As major regulators of DNA replication in eukaryotes, minichromosome maintenance (MCM) proteins play an important role in the initiation and extension of DNA replication.
Baojie Wu, Shuyi Xi
semanticscholar +2 more sources
Ιn vivo imaging of DNA-bound minichromosome maintenance complex in embryonic mouse cortex [PDF]
STAR Protocols, 2021 Summary: The recruitment of the minichromosome maintenance complex (MCM) on DNA replication origins is a critical process for faithful genome duplication termed licensing.
Maria Mougkogianni +4 more
doaj +2 more sources
Heterogeneous Expression Patterns of the Minichromosome Maintenance Complex Members in Retinoblastoma Unveil Its Clinical Significance [PDF]
Invest Ophthalmol Vis SciPurpose To explore the expression patterns and clinical significance of minichromosome maintenance (MCM) complex members in retinoblastoma (RB). Methods Single-cell RNA sequencing datasets from five normal retina, six intraocular, and five extraocular RB
Junjie Tang +13 more
semanticscholar +2 more sources
Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer [PDF]
Int J Biol Sci, 2022 Genomic instability is considered as one of the key hallmark during cancer development and progression. Cellular mechanisms, such as DNA replication initiation, DNA damage and repair response, apoptosis etc are observed to block progression of genomic ...
M. J. Mughal +5 more
semanticscholar +2 more sources
Correction to: Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 In the original publication of this article [1], the authors reported the order of the authors was incorrect and needs to be revised. The original article has been updated to rectify this error.
Qing Yang +9 more
doaj +5 more sources
Fundamental steps in Minichromosome Maintenance complex assembly are conserved from archaea to eukaryotes [PDF]
, 2023 Oliver W. Noble +4 more
openalex +2 more sources
Minichromosome maintenance protein 5 is an important pathogenic factor of oral squamous cell carcinoma [PDF]
Oncol Lett, 2020 Oral squamous cell carcinoma is one of the most common causes of malignancy-associated death. Early diagnosis of oral squamous cell carcinoma (OSCC) is important in patient treatment and prognostic evaluation.
Miao Hao +4 more
semanticscholar +2 more sources
Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma [PDF]
Oncol Rep, 2020 Esophageal squamous cell carcinoma (ESCC), the main subtype of esophageal cancer (EC), is a common lethal type of cancer with a high mortality rate. The aim of the present study was to select key relevant genes and identify potential mechanisms involved ...
Xue-bing Li +7 more
semanticscholar +2 more sources