METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway
Frontiers in Oncology, 2020 Methyltransferase-like 3 (METTL3), a major component of the N6-methyladenosine (m6A) methyltransferase complex, has been suggested to function as an oncogene in several cancers.
Dong-Dong Yang +11 more
doaj +1 more source
Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. [PDF]
, 2013 Deregulation of mini-chromosome maintenance (MCM) proteins is associated with genomic instability and cancer. MCM complexes are recruited to replication origins for genome duplication.
Brewster, Aaron +7 more
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Involvement of DNA superhelicity in minichromosome maintenance in Escherichia coli [PDF]
Journal of Bacteriology, 1985 Evidence is presented that Escherichia coli minichromosomes are harbored at superhelical densities which are lower than those measured for other E. coli plasmids but are comparable to that of the chromosome. When introduced into gyrB decreased-supercoiling mutants, minichromosomes were much more unstable than in strains with normal or increased ...
A C, Leonard +2 more
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Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +1 more source
The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids
Current Issues in Molecular Biology, 2021 Uterine fibroids are the most common mesenchymal uterine neoplasms; their prevalence is estimated in 40%–60% of women under 35 and in 70%–80% of women over 50 years of age.
Piotr Rubisz +2 more
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Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Endoreplication Cycles [PDF]
The Journal of Cell Biology, 1998 Minichromosome maintenance (MCM) proteins are essential eukaryotic DNA replication factors. The binding of MCMs to chromatin oscillates in conjunction with progress through the mitotic cell cycle. This oscillation is thought to play an important role in coupling DNA replication to mitosis and limiting chromosome duplication to once per cell cycle.
Su, Tin Tin, O'Farrell, Patrick H
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Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough +30 more
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Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis [PDF]
Oncogene, 2006 Minichromosomal maintenance protein 7 (MCM7) is an essential component of the replication helicase complex (MCM2-7) required for DNA replication. Although this function is highly conserved among eukaryotes, additional functions for the MCM molecules continue to be described.
K A, Honeycutt +7 more
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The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription [PDF]
, 2014 peer reviewedThe Tax oncoprotein plays a key role in the mechanisms of transformation, viral persistence and pathogenicity. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication
Pierre-Yves Barez +3 more
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Over expression of minichromosome maintenance genes is clinically correlated to cervical carcinogenesis. [PDF]
PLoS ONE, 2013 Minichromosome Maintenance (MCM) proteins play important roles in cell cycle progression by mediating DNA replication initiation and elongation. Among 10 MCM homologues MCM 2-7 form a hexamer and assemble to the pre-replication complex acting as ...
Mitali Das +7 more
doaj +1 more source