Results 81 to 90 of about 1,224,373 (238)

Chromosome Association of Minichromosome Maintenance Proteins in Drosophila Mitotic Cycles [PDF]

The Journal of Cell Biology, 1997
Minichromosome maintenance (MCM) proteins are essential DNA replication factors conserved among eukaryotes. MCMs cycle between chromatin bound and dissociated states during each cell cycle. Their absence on chromatin is thought to contribute to the inability of a G2 nucleus to replicate DNA.
Su, Tin Tin, O'Farrell, Patrick H
openaire   +4 more sources

Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere. [PDF]

, 2018
In addition to its roles in transcription and replication, topoisomerase 2 (topo 2) is crucial in shaping mitotic chromosomes and in ensuring the orderly separation of sister chromatids.
Farr, Christine J, Fukagawa, Tatsuo, Mills, Walter E, Spence, Jennifer M   +3 more
core   +1 more source

High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein

Applied Bionics and Biomechanics, 2022
Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome maintenance family that is necessary for the initiation of eukaryotic DNA replication.
Xin Zhang, Hui Chen, Hui Lin, Ronglan Wen, Fan Yang   +4 more
doaj   +1 more source

Minichromosome maintenance complex component 8 mutations cause primary ovarian insufficiency [PDF]

Fertility and Sterility, 2016
To investigate whether mutations in the minichromosome maintenance complex component 8 (MCM8) gene were present in 192 patients with sporadic primary ovarian insufficiency (POI).Retrospective case-control cohort study.University-based reproductive medicine center.A total of 192 patients with sporadic POI and 312 control women with regular menstruation (
Xiaoyun, Dou, Ting, Guo, Guangyu, Li, LiGuang, Zhou, Yingying, Qin, Zi-Jiang, Chen   +5 more
openaire   +2 more sources

SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]

, 2011
Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter, Beth A. Sullivan, Delphine Theodorou, Edoardo Petrini, Felix Krueger, J. Ross Miller, Konrad Paszkiewicz, Margaret R. Crawford, Mickaël Durand-Dubief, Nicholas A. Kent, Patrick Varga-Weisz, Rachael R. Harris, Rosa Maria Correra, William Ryan Will   +13 more
core   +4 more sources

Investigating the role of minichromosome maintenance protein 2 in differentiating follicular adenoma from follicular carcinoma of thyroid

American Journal of Experimental and Clinical Research, 2021
Thyroid nodules are often discovered incidentally in the clinical practice. Even though definite preoperative diagnosis of follicular thyroid lesions prevents unnecessary thyroid surgeries, fine needle aspiration (FNA) cannot definitely differentiate ...
Mahmood Akhavan Tafti, Zahra Kargar, Shokouh Taghipour zahir, Mehrdad Roozbeh, Somayeh Zabihi Mahmoodabadi, Aliasghar Kheirkhah Vakilabad, Farzan Safi Dahaj   +6 more
doaj  

Deregulation of the Replisome Factor MCMBP Prompts Oncogenesis in Colorectal Carcinomas through Chromosomal Instability

Neoplasia: An International Journal for Oncology Research, 2014
Genetic instability has emerged as an important hallmark of human neoplasia. Although most types of cancers exhibit genetic instability to some extent, in colorectal cancers genetic instability is a distinctive characteristic.
Mauricio Quimbaya, Eric Raspé, Geertrui Denecker, Bram De Craene, Ria Roelandt, Wim Declercq, Xavier Sagaert, Lieven De Veylder, Geert Berx   +8 more
doaj   +1 more source

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.

PLoS Pathogens, 2022
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), serving as the viral persistence form and transcription template of HBV infection, hijacks host histone and non-histone proteins to form a minichromosome and utilizes posttranslational ...
Elena S Kim, Jun Zhou, Hu Zhang, Alexander Marchetti, Maarten van de Klundert, Dawei Cai, Xiaoyang Yu, Bidisha Mitra, Yuanjie Liu, Mu Wang, Ulrike Protzer, Haitao Guo   +11 more
doaj   +1 more source

The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]

, 2017
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Bai, Yuchen, Kwok, Hang Fai, Mahadevappa, Ravikiran, McCrudden, Cian M, Neves, Henrique, Wen, Qing, Yuen, Hiu Fung, Yuen, Shun Ming, Zhang, Shu Dong   +8 more
core   +3 more sources

The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans

Biology, 2023
Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward ...
Bik-Kwoon Tye, Yuanliang Zhai
doaj   +1 more source