Results 131 to 140 of about 13,357,463 (271)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Efficacy of Upadacitinib in Patients with Atopic Dermatitis of the Head and Neck Region

Dermatology and Therapy
Introduction Head and neck atopic dermatitis (AD) is difficult to treat. We evaluated the efficacy of upadacitinib versus placebo in patients with head and neck AD in a post hoc analysis of Measure Up 1 (NCT03569293) and Measure Up 2 (NCT03607422 ...
Kilian Eyerich, Pedro Mendes-Bastos, Gregor Holzer, Vipul Jain, Norito Katoh, Paula C. Luna, Pablo Coto Segura, Michael Lane, Ayman Grada, Alvaro Moreira, Christopher G. Bunick   +10 more
doaj   +1 more source

Residual disease activity in psoriatic arthritis: discordance between the rheumatologist's opinion and minimal disease activity measurement

Rheumatology (Oxford, England), 2018
Objective. To assess how many PsA patients with an acceptable disease state according to the treating rheumatologist have quiescent disease defined as minimal disease activity (MDA). Methods. This cross-sectional study included 250 PsA patients. To assess current clinical practice as closely as possible, acceptable disease state was not determined by ...
van Mens, Leonieke J. J., Turina, Maureen C., van de Sande, Marleen G. H., Nurmohamed, Mike T., van Kuijk, Arno W. R., Baeten, Dominique L. P.   +5 more
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Minimal disease activity and remission in patients with psoriatic arthritis with elevated body mass index: an observational cohort study in the Swiss Clinical Quality Management cohort. [PDF]

BMJ Open, 2022
Vallejo-Yagüe E, Burkard T, Micheroli R, Burden AM.   +3 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Associations of Acute Phase Reactants with Disease Activity and Radiological Involvement in Pulmonary Tuberculosis

Background: Smear microscopy is widely used in diagnosing tuberculosis (TB), but its sensitivity may be limited in cases with low bacillary load or extrapulmonary involvement. This has led to growing interest in laboratory biomarkers that reflect disease
Murat Yalçınsoy, Yalçınsoy, Murat, Akkaya, Esen, Pakize Sucu, Eylem Tunçay, Bülbül, Esra Usta, Esra Usta Bülbül, Abdurrahman Yılmaz, Sucu, Pakize, Yılmaz, Abdurrahman, Gungor, Sinem, Esen Akkaya, Sinem Güngör, Tunçay, Eylem   +13 more
core   +1 more source

Measurement of Minimal Disease Activity in Psoriatic Arthritis Using the Patient-Reported Outcomes Measurement Information System-Physical Function or the Health Assessment Questionnaire Disability Index. [PDF]

Arthritis Care Res (Hoboken), 2022
Chew E, Perin J, Grader-Beck T, Orbai AM.   +3 more
europepmc   +1 more source

Association of Systemic Lupus Erythematosus with Dyslipidemia

Pakistan Armed Forces Medical Journal
Objective: To find out the association between Systemic Lupus Erythematosus (SLE) disease activity and lipid profile of patients. Study Design: Cross Sectional Study. Place and Duration of Study: Khyber Teaching Hospital, Peshawar Pakistan, from May
Muhammad Imran, Hajra Ahmad, Alam Zeb, Najib Ullah, Usman Ali, Almas Khan   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source