Results 151 to 160 of about 13,357,463 (271)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

MCID/Low Disease Activity State Workshop: low disease activity state in rheumatoid arthritis.

, 2003
Item does not contain fulltextThe MCID (minimal clinically important difference) module of OMERACT 5 developed a research agenda that led to the conclusion that a state of low disease activity for rheumatoid arthritis (RA) would need to be defined.
Kirwan, J., Wells, George, Riel, P.L.C.M. van, Boers, M., Johnson, K., Anderson, J., Tugwell, Peter, Anderson, Jennifer, Strand, Vibeke, Boers, Maarten, Felson, David, Simon, L.S., Shea, Beverley, Van Riel, Piet, Kirwan, John, Johnson, Kent, Lassere, M.N., Lassere, Marissa, Robinson, Vivian, Simon, Lee, Robinson, V., Strand, V., Felson, D.T., Tugwell, P.S., Wells, G.A., Shea, B.   +25 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Alemtuzumab in the up-front setting

Therapeutics and Clinical Risk Management, 2008
Matthew Kaufman, Kanti R RaiLong Island Jewish Medical Center, New Hyde Park, NY, USAAbstract: Alemtuzumab is a humanized chimeric monoclonal antibody targeting CD52.
Matthew Kaufman, Kanti R Rai
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comment on: Residual disease activity in psoriatic arthritis: discordance between the rheumatologist’s opinion and minimal disease activity measurement: reply [PDF]

Rheumatology, 2017
van Mens, Leonieke J. J., van de Sande, Marleen G. H., Baeten, Dominique L. P.   +2 more
openaire   +3 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Minimal disease activity linked to better outcomes in PsA [PDF]

Nature Reviews Rheumatology, 2015
openaire   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Association Between Fish Consumption and Minimal Disease Activity in Patients With Rheumatoid Arthritis Receiving Molecular-Targeted Therapies. [PDF]

Int J Rheum Dis
Tarumi M, Amengual O, Navidad M, Oki Y, Yasuda M, Kosumi Y, Takeyama S, Yoshimura M, Ninagawa K, Aso K, Hisada R, Nakamura H, Kono M, Fujieda Y, Kato M, Nakamura A, Kumagai S, Cáliz R, Atsumi T.   +18 more
europepmc   +1 more source