Results 31 to 40 of about 23,496 (231)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Minimal Seesaw as an Ultraviolet Insensitive Cure for the Problems of Anomaly Mediation
, 2007 We show that an intermediate scale supersymmetric left-right seesaw scenario with automatic R-parity conservation can cure the problem of tachyonic slepton masses that arises when supersymmetry is broken by anomaly mediation, while preserving ultraviolet
N. Setzer +4 more
core +2 more sources
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Deformed Special Relativity from Asymptotically Safe Gravity
, 2010 By studying the notion of a fundamentally minimal length scale in asymptotically safe gravity we find that a specific version of deformed special relativity (DSR) naturally arises in this approach.
Calmet, Xavier +2 more
core +1 more source
Search for Particles and Forces Beyond the Standard Model at HERA ep and Tevatron p\bar{p} Colliders [PDF]
, 2002 A review of searches for physics beyond the Standard Model carried out at high energy lepton-hadron and hadron-hadron facilities is presented, with emphasis on topics of interest for future data taking at the upgraded Tevatron $p{\bar p}$ and HERA $ep ...
Kuze, Masahiro, Sirois, Yves
core +4 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
On the strong partition dimension of graphs [PDF]
, 2013 We present a different way to obtain generators of metric spaces having the property that the ``position'' of every element of the space is uniquely determined by the distances from the elements of the generators.
Yero, Ismael Gonzalez
core
Supercoset CFT's for String Theories on Non-compact Special Holonomy Manifolds [PDF]
, 2003 We study aspects of superstring vacua of non-compact special holonomy manifolds with conical singularities constructed systematically using soluble N = 1 superconformal field theories (SCFT's).
Acharya +123 more
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source