Results 81 to 90 of about 1,438,673 (245)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Preclinical Efficacy and Safety Evaluation of a Novel Controlled‐Expansion ePTFE‐Covered TIPS Stent in a Swine Model

Portal Hypertension &Cirrhosis, EarlyView.
This preclinical study evaluated a novel controlled‐expansion expanded polytetrafluoroethylene (ePTFE)‐covered transjugular intrahepatic portosystemic shunt (TIPS) stent in 11 swine, demonstrating 100% technical success, excellent deployability, and durable 6‐month angiographic patency without thrombosis, migration, fracture, or device‐related toxicity.
Yi Xiang, Qi Zhang, Chuan Liu, Jiawei Zhang, Qingqiao Zhang, Changsheng Shi, Chunze Zhou, Yudong Zhang, Hongliang He, Hao Xie, Hui Shi, Haijian Guo, Wenjing Liu, Muqing Lin, Huajie Yu, Xiaolong Qi   +15 more
wiley   +1 more source

[Minimal hepatic encephalopathy].

Revista de gastroenterologia de Mexico, 2014
Minimal hepatic encephalopathy (MHE) is defined by the presence of neurophysiological alterations,with an important impact in the quality of life, in the risk of performing dangerous tasks as leading cars and heavy machinery and increases risk of overt hepatic encephalopathy.
M, Jover, E, Hoyas, L, Grande, M, Romero-Gómez   +3 more
openaire   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

A survey of patterns of practice and perception of minimal hepatic encephalopathy: A nationwide survey in India

The Saudi Journal of Gastroenterology, 2014
Background/Aim: Minimal hepatic encephalopathy (MHE) leads to overt hepatic encephalopathy (HE) and impairs quality of life in patients with cirrhosis. Awareness of MHE and its management among physicians is not known.
Praveen Sharma, Barjesh C Sharma
doaj   +1 more source

The treatment of hepatic encephalopathy

, 2007
Current recommendations for the treatment of hepatic encephalopathy are based, to a large extent, on open or uncontrolled trials, undertaken in very small numbers of patients.
M. Y. Morgan, R. Jalan, G. Marchesini, Karin Weissenborn, G. Kircheis, RIGGIO, Oliviero, MARCHESINI REGGIANI, GIULIO, A. Blei, K. Weissenborn, W. Fleig, K. Grungreiff, Marsha Y. Morgan, O. Riggio   +12 more
core   +1 more source

Skeletal Muscle Mass Improvement and Survival After TIPS in Patients With Cirrhosis and Low Skeletal Muscle Index

Portal Hypertension &Cirrhosis, EarlyView.
Sarcopenia is common in patients with cirrhosis and contributes to poor prognosis. This study investigated whether transjugular intrahepatic portosystemic shunt (TIPS) is associated with improvement in skeletal muscle mass and whether such improvement translates into better transplant‐free survival in patients with cirrhosis and low skeletal muscle ...
Qinnian Li, Jiamin Xu, Chenrui Zhang, Rongfang Tu, Weimin Bao, Yingmei Tang   +5 more
wiley   +1 more source

Minimal hepatic encephalopathy

, 2018
The term minimal hepatic encephalopathy (MHE) refers to the subtle changes in cognitive function, electrophysiological parameters, cerebral neurochemical/neurotransmitter homeostasis, cerebral blood flow, metabolism, and fluid homeostasis that can be ...
Torre Delgadillo, Aldo, Zamora Nava, Luis Eduardo   +1 more
core  

Real‐World Distribution and Mortality Assessment of MDF and MELD Scores in Hospitalized Patients With Alcohol‐Associated Cirrhosis and Clinically Diagnosed Alcohol‐Associated Hepatitis

Portal Hypertension &Cirrhosis, EarlyView.
This single‐center, retrospective study evaluated MDF, MELD, and etiology‐adjusted MELD (MELD[A]) scores in 92 hospitalized patients with alcohol‐associated cirrhosis and clinically diagnosed alcohol‐associated hepatitis. Six patients were lost to follow‐up and excluded from survival analyses (final n = 86).
Ya Su, Xinyu Hu, Yin Long, Xigu Rigan, Rina Na, Han Baiyila, Jie Li, Bingyuan Wang   +7 more
wiley   +1 more source