Results 61 to 70 of about 1,438,673 (245)

Population pharmacokinetics of levetiracetam in term neonates with hypoxic–ischemic encephalopathy and therapeutic hypothermia: The LEVNEONAT‐1 study

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram, Moreno Ursino, Julie Leger, Emilie Bourrel‐Ponchel, Florence Flamein, Alexandra Chadie, Isabelle Guellec, Sarah Zohar, Vincent Jullien, Géraldine Favrais   +9 more
wiley   +1 more source

A Practical Guide to Implementing Real‐World Evidence as Primary Basis for Approval and Label Expansion

Clinical Pharmacology &Therapeutics, EarlyView.
In June 2026, the FDA issued a revised draft guidance describing the circumstances in which one adequate and well‐controlled clinical investigation plus confirmatory evidence may satisfy the statutory substantial evidence standard for establishing efficacy and safety. Confirmatory evidence includes real‐world evidence (RWE).
Tracy J. Mayne, Maurice A. Brookhart, Nancy A. Dreyer   +2 more
wiley   +1 more source

Attention: Minimal hepatic encephalopathy and road accidents [PDF]

Hepatology, 2012
editorial
AMODIO, PIERO, MONTAGNESE, SARA, MERKEL, CARLO   +2 more
openaire   +3 more sources

Exploring medical food supplementation as an adjunct strategy for microbiota restoration and seizure reduction in CDKL5 deficiency disorder

Epilepsia Open, EarlyView.
Abstract Objectives CDKL5 deficiency disorder (CDD) is a developmental and epileptic encephalopathy characterized by early‐onset, treatment‐resistant seizures and severe neurodevelopmental impairment. Increasing evidence suggests that alterations in the gut–brain axis may contribute to disease pathophysiology, raising interest in microbiota‐targeted ...
Elisa Borghi, Matteo Domenico Marsiglia, Francesca Triva, Emerenziana Ottaviano, Ilaria Viganò, Miriam Nella Savini, Valentino Costabile, Aglaia Vignoli   +7 more
wiley   +1 more source

First Latin American consensus on the treatment and prophylaxis of hepatic encephalopathy

Annals of Hepatology
Introduction and Objectives: Hepatic encephalopathy (HE) is a frequent and severe complication of cirrhosis, leading to rapid deterioration and increased mortality.
Fátima Higuera-de-la-Tijera, Mario Reis Alvares-da-Silva, Graciela Elia Castro-Narro, Josué Barahona-Garrido, Enrique Carrera-Estupiñán, Jorge Garavito-Rentería, Héctor Adolfo Henríquez-Meléndez, Geovanny Hernández-Cely, Javier Mora-Lazo, Manuel Mendizabal, Gabriel Alejandro Mezzano-Puentes, Claudia P. Oliveira, Mário Guimarães Pessoa, Yanette Suárez-Quintero, José Antonio Velarde-Ruiz Velasco   +14 more
doaj   +1 more source

Hepatic encephalopathy. Clinical case [PDF]

, 2021
Hepatic encephalopathy is a neuropsychiatric syndrome associated with abnormal liver function and portosystemic venous shunting. According to the West-Haven classification, depending on the degree of neurological disorders, there are minimal, I - IV ...
Natalia Rafalska, Rafalska, Natalia
core   +1 more source

Detecção de encefalopatia hepática mínima através de testes neuropsicológicos e neurofisiológicos e o papel da amônia no seu diagnóstico Minimal hepatic encephalopathy detection by neuropsychological and neurophysiological methods and the role of ammonia for its diagnosis

Arquivos de Gastroenterologia, 2009
CONTEXTO: A encefalopatia hepática mínima vem sendo sistematicamente investigada em pacientes com cirrose hepática. Entretanto, existem controvérsias quanto aos melhores métodos, bem como o papel da amônia para seu diagnóstico.
Maurício Augusto Bragagnolo Jr., Vinícius Teodoro, Lígia Mendonça Lucchesi, Tarsila Campanha da Rocha Ribeiro, Sérgio Tufik, Mário Kondo   +5 more
doaj   +1 more source

Hepatic Sinusoidal Obstruction Syndrome Induced by Pyrrolizidine Alkaloids: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Innovations

iNew Medicine, EarlyView.
ABSTRACT Hepatic sinusoidal obstruction syndrome (HSOS) is a microcirculatory disorder of the liver that poses a serious threat to human health. Pyrrolizidine alkaloids (PAs), a class of toxins widely found in plants, are often ingested accidentally and are one of the major causes of HSOS.
Fumin Zhang, Cheng Zhu, Xingyu Li, Yaoling Zhu, Domingo Antonio Sánchez Martínez, Ying Dai, Lifeng Guo, Derun Kong   +7 more
wiley   +1 more source

Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of Ascelia‐Manganese‐Based MRI Contrast Agent (ACE‐MBCA) in Adult Subjects With and Without Hepatic Impairment

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Orally administered Ascelia‐manganese‐based contrast agent (ACE‐MBCA) is used for liver MRI, but its feasibility in patients with hepatic dysfunction remains unknown. Purpose To investigate the pharmacokinetics (PK), pharmacodynamics, and safety of ACE‐MBCA in subjects without/with hepatic impairment.
Amit G. Singal, Eric Lawitz, Andreas Norlin, Nadilka Hettiarachchige, Thomas Bengtsson, Bachir Taouli   +5 more
wiley   +1 more source

Minimal Hepatic Encephalopathy (MHE) [PDF]

, 2012
None
Daniela Benedeto-Stojanov, Dragan Stojanov   +1 more
openaire   +2 more sources