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Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan   +7 more
wiley   +1 more source
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Post minimal intervention

The Conservator, 2004
Abstract Minimal intervention, as an approach to the structural conservation of canvas paintings, is first examined as an aspect of the construction of the image of the modern conservator. Its evolution and relationship with other significant concepts (reversibility, history of the object, preventive conservation) are then considered.
exaly   +2 more sources

Minimal Intervention Dentistry

2023
Minimally invasive treatment of dental caries is an approach that uses conservative management strategies focusing on maximum preservation of tooth structure. Unlike the principles enumerated by GV Black, which advocated maximal excavation of carious tooth structure, Minimal Invasive Dentistry (MID) conserves as much tooth structure as possible and ...
Arthur M. Kemoli   +2 more
openaire   +1 more source

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