Results 21 to 30 of about 144,448 (193)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Codimension and pseudometric in co-Heyting algebras [PDF]
, 2008 In this paper we introduce a notion of dimension and codimension for every element of a distributive bounded lattice $L$. These notions prove to have a good behavior when $L$ is a co-Heyting algebra.
Faculte ́ Des Sciences +2 more
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Free three-valued Closure Lukasiewicz Algebras [PDF]
, 2007 In this paper, the structure of finitely generated free objects in the variety of three-valued closure Lukasiewicz algebras is determined. We describe their indecomposable factors and we give their cardinality.Fil: Abad, Manuel.
Abad, Manuel +3 more
core +1 more source
Valued fields, Metastable groups
, 2018 We introduce a class of theories called metastable, including the theory of algebraically closed valued fields (ACVF) as a motivating example. The key local notion is that of definable types dominated by their stable part.
Hrushovski, Ehud, Rideau, Silvain
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Countable Chain Condition for C*-Algebras [PDF]
, 2014 In this paper, we introduce the countable chain condition for C*-algebras and study its fundamental properties. We show independence from ZFC of the statement that this condition is preserved under the tensor products of C*-algebras.Comment: 9 ...
Masumoto, Shuhei
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