Results 111 to 120 of about 1,685,550 (310)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Rfa1-MN-based system reveals new factors involved in the rescue of broken replication forks.

PLoS Genetics
The integrity of the replication forks is essential for an accurate and timely completion of genome duplication. However, little is known about how cells deal with broken replication forks.
Ana Amiama-Roig, Marta Barrientos-Moreno, Esther Cruz-Zambrano, Luz M López-Ruiz, Román González-Prieto, Gabriel Ríos-Orelogio, Félix Prado   +6 more
doaj   +1 more source

Elective Open Suprarenal Aneurysm Repair in England from 2000 to 2010 an Observational Study of Hospital Episode Statistics [PDF]

, 2013
Background: Open surgery is widely used as a benchmark for the results of fenestrated endovascular repair of complex abdominal aortic aneurysms (AAA).
Hinchliffe, RJ, Jan D Poloniecki, Thompson, MM, Holt Peter J. E., Sollazzo Giuseppe, Hinchliffe Robert J., Alan Karthikesalingam, Robert J Hinchliffe, Matthew M Thompson, Peter J E Holt, Poloniecki, JD, Karthikesalingam, A, Patterson Benjamin O., Thompson Matthew M., Benjamin O Patterson, Giuseppe Sollazzo, Holt, PJ, Vidal-Diez, A, Sollazzo, G, Vidal-Diez Alberto, Karthikesalingam Alan, Patterson, BO, Alberto Vidal-Diez, Poloniecki Jan D.   +23 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

composite biomaterials for bone repair

, 2018
The fast replacement of native functionality (i.e., biological, chemical, mechanical) of damaged skeletal tissues currently represents the main challenge of clinical surgery.
Roberto De santis, Vincenzo Guarino, Luigi Ambrosio   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Suppressed Expression of Non-DSB Repair Genes Inhibits Gamma-radiation Induced Cytogenetic Repair And Cell Cycle Arrest [PDF]

, 2008
Changes of gene expression profile are one of the most important biological responses in living cells after ionizing radiation (IR) exposure. Although some studies have shown that genes up-regulated by IR may play important roles in DNA damage repair ...
Rohde, Larry
core   +1 more source

No clinical differences between outside-in and all-inside techniques in medial meniscus repair: emphasizing Minimal Clinically Important Difference (MCID) -based outcomes

BMC Musculoskeletal Disorders
Background While the all-inside (AI) technique is widely preferred for its simplicity and efficiency, the outside-in (OI) method is less commonly used. Despite both techniques being effective, direct comparisons of their functional outcomes are limited ...
Aytek Hüseyin Çeliksöz, Ceyhun Çağlar, Serhat Akçaalan, Kenan Şen, Cevaydin Güler, Ali Okan Tarlacık, Ali Engin Daştan, Arman Vahabi   +7 more
doaj   +1 more source