Results 91 to 100 of about 669,953 (290)

Fourteen Years of Living with Instability: A Case of Chronic Recurrent Anterior Shoulder Dislocation in a Middle-Aged Athlete

Journal of Orthopaedic Case Reports
Introduction: Recurrent anterior shoulder dislocation is a common sequela of traumatic shoulder injury in young adults, particularly athletes. Delayed treatment often leads to complex pathoanatomy, including Bankart and Hill-Sachs lesions.
Karthick Adhavan, P M Mervin Rosario, T P Muthu Akilan   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dumbbell technique for iridodialysis repair

Indian Journal of Ophthalmology
We describe a novel, simple and minimally invasive surgical technique for the repair of iridodialysis, which can be easily adopted by general ophthalmologists and cataract surgeons.
Anjali Khadia, Rengaraj Venkatesh, Fredrick Moutappa, Arpit Gupta, Swati Upadhyaya   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A discounted model for a repairable system with continuous state space [PDF]

, 2000
We examine repairable systems with a continous state space and partial repair options, carried out at fixed times $n=1,2,...$. Every time interval $[n,n+1)$ there is a manufacturing cost and a repair cost.
Bruns, P.B.
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pushing boundaries in cardiac surgery: minimally invasive mitral valve repair combined with tricuspid valve repair and/or other concomitant procedures

Frontiers in Cardiovascular Medicine
IntroductionMinimally invasive mitral valve repair/replacement has emerged as a widely accepted surgical approach for managing mitral valve disorders.
Marie-Elisabeth Stelzmueller, Robert Zilberszac, Raphael Rosenhek, Doris Hutschala, Sabine Kappel, Andrea Lassnig, Guenther Laufer, Daniel Zimpfer, Wilfried Wisser   +8 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Vesicovaginal fistula: Review and recent trends

Indian Journal of Urology, 2019
Vesicovaginal fistula (VVF) is an abnormal communication between the bladder and the vagina. Prompt diagnosis and timely repair are essential for successful management of these cases. As the clinical scenario is variable, it is difficult to frame uniform
Shanmugasundaram Rajaian, Murugavaithianathan Pragatheeswarane, Arabind Panda   +2 more
doaj   +1 more source

A Review of integrity constraint maintenance and view updating techniques [PDF]

, 2003
Two interrelated problems may arise when updating a database. On one hand, when an update is applied to the database, integrity constraints may become violated.
Mayol Sarroca, Enric, Teniente López, Ernest   +1 more
core   +1 more source