Results 81 to 90 of about 1,685,550 (310)

Investigation of DNA repair in human oocytes and preimplantation embryos [PDF]

, 2010
DNA repair genes are expressed in mammalian embryos and in human germinal vesicles, however, little is known about DNA repair in human preimplantation embryos.
Jaroudi, S.
core  

Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]

, 2006
The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC, Savitzky, MH, Sunjevaric, [No Value], Rothstein, R, Marrero, VA, Thorpe, PH   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Robotic repair of large Morgagni hernia in an adolescent girl

Journal of Pediatric Surgery Case Reports, 2019
Introduction: Successful robotic repair of Morgagni hernias has been reported a few times, but in these cases the hernia content was rather minimal or unspecified.
Ward Janssens, Martijn Schoneveld, Mathias Allaeys, Antoine De Backer   +3 more
doaj   +1 more source

Minimal repair under a step-stress test

Statistics & Probability Letters, 2009
In the one- and multi-sample cases, in the context of life-testing reliability experiments, we introduce minimal repair processes under a simple step-stress test, based on exponential distributions and an associated cumulative exposure model, and then develop likelihood inference for such a model.
Kateri, M., Balakrishnan, N., Kamps, U.
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

All-Arthroscopic Intratendinous Dermal Patch Integration for Large-Sized Rotator Cuff Tear

Arthroscopy Techniques
Patch augmentation of rotator cuff repair can create a healed tendon-bone interface, rather than the formation of a fibrovascular scar tissue, seen even after maximizing biomechanical strength of repair with a double-row construct.
Sreejith Thampy J., M.S. Ortho, Yon-Sik Yoo, M.D., Ph.D., Ayyappan V. Nair, D.N.B., M.N.A.M.S.   +2 more
doaj   +1 more source

Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study

Nanomaterials, 2019
Ventral or incisional hernia are a common disease pattern in general surgery. Most commonly, a mesh repair is used for reconstruction, whereby the mesh itself might cause complications, like infections or adhesions.
Falk Rauchfuß, Julian Helble, Johanna Bruns, Olaf Dirsch, Uta Dahmen, Michael Ardelt, Utz Settmacher, Hubert Scheuerlein   +7 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source