Results 61 to 70 of about 664,402 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Arthroscopic 2-Portal Technique Using Percutaneous Spinal Needle Suture Passing With Suture Anchors for the Treatment of Calcific Insertional Achilles Tendinopathy

Arthroscopy Techniques
Endoscopic techniques for insertional calcific tendinopathy of the Achilles tendon have the benefits of reduced perioperative pain, minimal scarring, minimal blood loss, and quicker recovery times. However, the limited visualization provided by endoscopy
Yizhong Peng, M.D., Ph.D., Wenbo Yang, M.D., Ph.D., Yi Li, M.B.B.S., Chunqing Meng, M.D., Ph.D., Hong Wang, M.D., Ph.D., Wei Huang, M.D., Ph.D.   +5 more
doaj   +1 more source

Assessment of Kinematics and Electromyography Following Arthroscopic Single-Tendon Rotator Cuff Repair [PDF]

, 2017
Background The increasing demand for rotator cuff (RC) repair patients to return to work as soon as they are physically able has led to exploration of when this is feasible. Current guidelines from our orthopedic surgery clinic recommend a return to work
Fritz, Jessica M, Grindel, Steven I., Harris, Gerald F., Inawat, Ryan R., McGuire, John R., Slavens, Brooke A., Tarima, Sergey S., Ziegler, Dean W.   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Penile fracture: A case report from Nepal

Clinical Case Reports, 2021
Penile fractures are clinically diagnosed with eggplant‐like deformity of the penis (aubergine sign). Surgical repair immediately following the penile fracture is the standard of care, which usually heals with minimal or no complications.
Alok Atreya, Suman Baral
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Clinical outcomes of over-the-top subscapularis repair in reverse shoulder arthroplasty

JSES International
Background: Biomechanical research demonstrates increased subscapularis abduction range of motion (ROM) when the tendon’s upper two-thirds is repaired over-the-top of the center of rotation during reverse shoulder arthroplasty (RSA).
Robert J. Cueto, BS, Kevin A. Hao, BS, Daniel S. O’Keefe, BS, Marlee A. Mallat, BS, Keegan M. Hones, MD, Lacie M. Turnbull, MD, Jonathan O. Wright, MD, Jose Soberon, MD, Bradley S. Schoch, MD, Joseph J. King, MD   +9 more
doaj   +1 more source

Modified Extensive Anterior Vaginal Wall Repair for Cystocoele [PDF]

, 2010
We describe a new transvaginal technique for cystocoele repair. We prospectively evaluated patients with moderate and high-grade cystocoele who underwent repair with the new transvaginal repair between 2000 and June 2009. Preoperative evaluation included
Anton Maričić, Antun Gršković, Dražen Rahelić, Maksim Valenčić, Romano Oguić, Stanislav Sotošek   +5 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source