Results 81 to 90 of about 664,402 (295)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exchange-Repairs: Managing Inconsistency in Data Exchange

, 2014
In a data exchange setting with target constraints, it is often the case that a given source instance has no solutions. In such cases, the semantics of target queries trivialize.
A. Fuxman, J. Chomicki, M.C. Marileo, N. Leone, R. Fagin, T. Janhunen   +5 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Arthroscopic Repair of Extensor Carpi Radialis Brevis in Patients With Tennis Elbow

Arthroscopy Techniques
Lateral epicondylitis, or tennis elbow, has been attributed to the degeneration of the extensor carpi radialis brevis tendon, with surgery reserved for recalcitrant cases.
Zhang Hailong, M.D., Ph.D., Lu Yi, M.D., Ph.D.   +1 more
doaj   +1 more source

Endovascular management of a late saccular aortic aneurysm after end-to-end repair of coarctation

Monaldi Archives for Chest Disease, 2015
Post-coarctation surgical repair aneurysm formation is observed rarely with end-to-end anastomosis technique. The redo surgery is associated with high mortality and morbidity rate.
Christophoros Kotoulas, Vasileios Tzilalis, Emmanouil Spyridakis, Ioannis Mamarelis   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Fourteen Years of Living with Instability: A Case of Chronic Recurrent Anterior Shoulder Dislocation in a Middle-Aged Athlete

Journal of Orthopaedic Case Reports
Introduction: Recurrent anterior shoulder dislocation is a common sequela of traumatic shoulder injury in young adults, particularly athletes. Delayed treatment often leads to complex pathoanatomy, including Bankart and Hill-Sachs lesions.
Karthick Adhavan, P M Mervin Rosario, T P Muthu Akilan   +2 more
doaj   +1 more source

Improved objective Bayesian estimator for a PLP model hierarchically represented subject to competing risks under minimal repair regime. [PDF]

PLoS One, 2021
Louzada F, Cuminato JA, Rodriguez OMH, Tomazella VLD, Ferreira PH, Ramos PL, Milani EA, Bochio G, Perissini IC, Gonzatto Junior OA, Mota AL, Alegría LFA, Colombo D, Perondi EA, Wentz AV, Júnior ALS, Barone DAC, Santos HFL, Magalhães MVC.   +18 more
europepmc   +1 more source

Arthroscopic anterior talofibular ligament repair for lateral instability of the ankle

, 2015
UNLABELLED: Although several arthroscopic procedures for lateral ligament instability of the ankle have been reported recently, it is difficult to augment the reconstruction by arthroscopically tightening the inferior extensor retinaculum.
Ankle Instability Group, Calder, JD, Glazebrook, MA, Guillo, S, Karlsson, J, Kennedy, JG, Matsui, K, Stone, JW, Takao, M   +8 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source