Minimal Residual Disease, Metastasis and Immunity [PDF]
Biomolecules, 2021 Progression from localized to metastatic disease requires cancer cells spreading to distant organs through the bloodstream. Only a small proportion of these circulating tumor cells (CTCs) survives dissemination due to anoikis, shear forces and ...
Jordi Badia-Ramentol +3 more
doaj +4 more sources
A systematic literature review and meta-analysis of minimal residual disease as a prognostic indicator in adult B-cell acute lymphoblastic leukemia [PDF]
Haematologica, 2019 Minimal (or ‘measurable’) residual disease in acute lymphoblastic leukemia appears to be a prognostic indicator, with potential value in informing individualized treatment decisions.
Renato Bassan +5 more
doaj +3 more sources
Assessment of Minimal Residual Disease in Standard-Risk AML [PDF]
New England Journal of Medicine, 2016 BACKGROUND: Despite the molecular heterogeneity of standard-risk acute myeloid leukemia (AML), treatment decisions are based on a limited number of molecular genetic markers and morphology-based assessment of remission.
Akiki, S +21 more
core +5 more sources
the value of minimal residual disease and diamonds [PDF]
Biology of Blood and Marrow Transplantation, 2016 n/
Adriana Balduzzi
core +6 more sources
Strategies for minimal residual disease detection: current perspectives [PDF]
Blood and Lymphatic Cancer: Targets and Therapy, 2019 Giacomo Andreani, Daniela Cilloni Department of Clinical and Biological Sciences, University of Turin, Turin, Italy Abstract: Currently, the post-remission treatment in acute leukemia is based on the genetic profile of leukemic cells at diagnosis (ie ...
Andreani G, Cilloni D
doaj +3 more sources
The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy [PDF]
Haematologica, 2014 A proportion of patients with chronic lymphocytic leukemia achieve a minimal residual disease negative status after therapy. We retrospectively evaluated the impact of minimal residual disease on the outcome of 255 consecutive patients receiving any ...
Rodrigo Santacruz +17 more
doaj +3 more sources
Metabolic memory underlying minimal residual disease in breast cancer [PDF]
Molecular Systems Biology, 2021 Tumor relapse from treatment‐resistant cells (minimal residual disease, MRD) underlies most breast cancer‐related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive.
Ksenija Radic Shechter +10 more
doaj +3 more sources
Minimal residual disease in multiple myeloma: current status
Biomarker Research, 2021 Multiple myeloma (MM) is a treatable plasma cell cancer with no cure. Clinical evidence shows that the status of minimal residual disease (MRD) after treatment is an independent prognostic factor of MM.
Hong Ding +12 more
doaj +2 more sources
A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia [PDF]
Haematologica, 2019 A high proportion of patients with acute myeloid leukemia who achieve minimal residual disease negative status ultimately relapse because a fraction of pathological clones remains undetected by standard methods.
Esther Onecha +21 more
doaj +8 more sources
Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review [PDF]
Journal of Translational Medicine, 2011 Background To evaluate the objective clinical outcomes of active specific immunotherapy (ASI) in advanced colorectal cancer (advanced CRC) and suspected minimal residual colorectal cancer (suspected minimal residual CRC).
Huang Jun +7 more
doaj +5 more sources