Results 41 to 50 of about 6,143,115 (301)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Variationally Improved Bézier Surfaces with Shifted Knots

open access: yesAdvances in Mathematical Physics, 2021
The Plateau-Bézier problem with shifted knots is to find the surface of minimal area amongst all the Bézier surfaces with shifted knots spanned by the admitted boundary.
Daud Ahmad   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Stability of vertical minimal surfaces in three-dimensional sub-Riemannian manifolds

open access: yesPracì Mìžnarodnogo Geometričnogo Centru
We obtain first and second variation formulae for minimal surfaces in three-dimensional sub-Riemannian manifolds which are vertical, i.e., perpendicular to the horizontal distribution of the sub-Riemannian structure.
Eugene Petrov, Ihor Havrylenko
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Minimal Languages in Action

open access: yes, 2021
This edited book explores the rising interest in minimal languages – radically simplified languages using cross-translatable words and grammar, fulfilling the widely-recognised need to use language which is clear, accessible and easy to translate.
Goddard, Cliff
core   +1 more source

On rectifying ruled surfaces

open access: yesKuwait Journal of Science, 2020
In this study, we define general rectifying ruled surfaces in the Euclidean 3-space E^3. We give some characterizations of rectifying ruled surfaces by considering the curvatures of base curve.
Mehmet Önder, Tanju Kahraman
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

On the minimal surfaces of Riemann

open access: yesCommentarii Mathematici Helvetici, 1992
Let \(\gamma_ 1\), \(\gamma_ 2\) be plane Jordan curves in horizontal planes \(P_ 1\), \(P_ 2\) of \(\mathbb{R}^ 3\). It is known, under simple conditions on \(\gamma_ 1\) and \(\gamma_ 2\), that they bound a least area minimal annulus between \(P_ 1\) and \(P_ 2\). \textit{W. H. Meeks III} and \textit{R. White} [Bull. Am. Math. Soc., New Ser.
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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