Results 61 to 70 of about 8,180 (214)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Bioinspired stochastic minimal surface metamaterials for tunable acoustic performance

Materials & Design
Conventional acoustic materials limit design flexibility, and hence, in this work, we introduce bioinspired stochastic metamaterials derived from minimal surface geometries as an alternative to traditional acoustic foams.
Kamal K Sirivuri, Vignesh Sekar, Wesley J Cantwell, Kin Liao, Benoit Berton, Nicolas Ravaud, Pierre-Marie Jacquart, Rashid K. Abu Al-Rub   +7 more
doaj   +1 more source

Stable Approximations of a Minimal Surface Problem with Variational Inequalities

Abstract and Applied Analysis, 1997
In this paper we develop a new approach for the stable approximation of a minimal surface problem associated with a relaxed Dirichlet problem in the space BV(Ω) of functions of bounded variation.
M. Zuhair Nashed, Otmar Scherzer
doaj   +1 more source

Minimal surfaces in AdS C-metric

Physics Letters B, 2017
We shed some light on the field theory interpretation of C-metric by investigating the minimal surfaces which are homologous to the given boundary regions. The accelerating black holes change the asymptotic structure of the space–time.
Hao Xu
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Cross-property relations for triply periodic minimal surface (TPMS) structures

Materials & Design
Triply periodic minimal surface (TPMS) structures are distinguished by their potential for multifunctional applications. Establishing cross-property relations within these microstructures enables rapid estimation of multiple physical properties and ...
Shouyi Wang, Zhao Xu, Chunrong Jiao, Haifeng Zhao   +3 more
doaj   +1 more source