Results 121 to 130 of about 2,059,946 (289)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Unstable Periodic Discrete Minimal Surfaces

open access: yes, 2002
this paper we define the new alignment energy for non-conforming triangle meshes, and describes its use to compute unstable conforming discrete minimal surfaces.
Konrad Polthier
core   +1 more source

Surfaces Modelling Using Isotropic Fractional-Rational Curves

open access: yesJournal of Applied Mathematics, 2019
The problem of building a smooth surface containing given points or curves is actual due to development of industry and computer technology. Previously used for those purposes, shells of zero Gaussian curvature and minimal surfaces based on isotropic ...
Igor V. Andrianov   +3 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Minimal surfaces over harmonic shears

open access: yes, 2023
Harmonic mappings have long intrigued researchers due to their intrinsic connection with minimal surfaces. In this paper, we investigate shearing of two distinct classes of univalent conformal mappings which are convex in horizontal direction with ...
Kumar, Sanjay, Bedi, Simran
core  

Meromorphic minimal surfaces [PDF]

open access: yesPacific Journal of Mathematics, 1962
Beckenbach, E. F., Hutchison, G. A.
openaire   +6 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

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