Results 111 to 120 of about 9,844,505 (300)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Surfaces Modelling Using Isotropic Fractional-Rational Curves

Journal of Applied Mathematics, 2019
The problem of building a smooth surface containing given points or curves is actual due to development of industry and computer technology. Previously used for those purposes, shells of zero Gaussian curvature and minimal surfaces based on isotropic ...
Igor V. Andrianov, Nataliia M. Ausheva, Yuliia B. Olevska, Viktor I. Olevskyi   +3 more
doaj   +1 more source

Modeling of Curvilinear Steel Rod Structures Based on Minimal Surfaces. [PDF]

Materials (Basel), 2021
Dzwierzynska J, Labuda I.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Geometry of branched minimal surfaces of finite index

Advanced Nonlinear Studies
Given I,B∈N∪{0} $I,B\in \mathbb{N}\cup \left\{0\right\}$ , we investigate the existence and geometry of complete finitely branched minimal surfaces M in R3 ${\mathbb{R}}^{3}$ with Morse index at most I and total branching order at most B. Previous works
Meeks William H., Pérez Joaquín
doaj   +1 more source

Minimal surfaces unveiled from the statistics of turbulent circulation fluctuations. [PDF]

Proc Natl Acad Sci U S A, 2021
Moriconi L.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Structural design and performance study of primitive triply periodic minimal surfaces Ti6Al4V biomimetic scaffold. [PDF]

Sci Rep, 2022
Qin Y, Wang Q, Shi C, Liu B, Ma S, Zhang M.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Design of a Haversian system-like gradient porous scaffold based on triply periodic minimal surfaces for promoting bone regeneration. [PDF]

J Adv Res, 2023
Li L, Wang P, Liang H, Jin J, Zhang Y, Shi J, Zhang Y, He S, Mao H, Xue B, Lai J, Zhu L, Jiang Q.   +12 more
europepmc   +1 more source