Results 91 to 100 of about 243,680 (259)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Design of a Haversian system-like gradient porous scaffold based on triply periodic minimal surfaces for promoting bone regeneration. [PDF]
J Adv Res, 2023 Li L +12 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the Hodge conjecture for products of certain surfaces [PDF]
, 2003 In this thesis we prove the Hodge conjecture for products of smooth projective surfaces S(_1) x S(_2), where S(_2) = A is an Abelian surface and S (_1) is such that P(_g)(S(_1)) = 1, q = 2.
J. Ramón Marí, José +1 more
core
, 2023 In this thesis, we present minimal surfaces and from where the interest in them comes. We start with the definition of the area functional and find its stationary point, a minimal surface. Consequently, we get a necessary condition for minimal surfaces i.
Derin, Tanja
core
Crashworthiness Design of Thin-Walled Tubes Reinforced by Triply Periodic Minimal Surfaces. [PDF]
3D Print Addit Manuf, 2021 Jiang Y, Wang S, Wang H, Li B, Hou W.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
A multiscale optimisation method for bone growth scaffolds based on triply periodic minimal surfaces. [PDF]
Biomech Model Mechanobiol, 2021 Lehder EF +4 more
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source