Results 71 to 80 of about 243,680 (259)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 1988 The behaviour of a certain class of periodic minimal surfaces is studied. It becomes evident that simple deformations along the crystallographic axes of these surfaces yield two sets of solutions to the boundary problem ; one stable and one unstable.
Sven Lidin
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Properties of Hyper-Elastic-Graded Triply Periodic Minimal Surfaces. [PDF]
Polymers (Basel), 2023 Haney CW, Siller HR.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Two-dimensional Newton's problem of minimal resistance
, 2006 Newton's problem of minimal resistance is one of the first problems of optimal control: it was proposed, and its solution given, by Isaac Newton in his masterful Principia Mathematica, in 1686. The problem consists of determining, in dimension three, the
Silva, C. J. +3 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Prediction of Cellular Structure Mechanical Properties with the Geometry of Triply Periodic Minimal Surfaces (TPMS). [PDF]
ACS Omega, 2023 Shevchenko V +3 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1993 This book contains recent results from a group focusing on minimal surfaces in the Moscow State University seminar on modern geometrical methods, headed by A. V. Bolsinov, A. T. Fomenko, and V. V. Trofimov. The papers collected here fall into three areas:
Fomenko, A T
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