Results 21 to 30 of about 271 (212)

Reducing the Structural Mass of Large Direct Drive Wind Turbine Generators through Triply Periodic Minimal Surfaces Enabled by Hybrid Additive Manufacturing

Clean Technologies, 2021
As the power output of direct drive generators increases, they become prohibitively large with much of this material structural support. In this work, implicit modeling was coupled to finite element analysis through a genetic algorithm variant to ...
Austin C. Hayes, Gregory L. Whiting
doaj   +1 more source

Optimal Response Surface Designs for Detection and Minimization of Model Contamination

Technometrics
Complete reliance on the assumed model in designing response surface experiments is risky and relaxing this assumption, whether out of necessity or intentionally, requires an experimenter to account for multiple conflicting objectives. This work provides a methodological framework of a multiple-component optimality criterion comprising individual ...
Olga Egorova, Steven G. Gilmour
openaire   +1 more source

Optimization of parameters of heat exchangers vehicles [PDF]

Transport Problems, 2014
The relevance of the topic due to the decision of problems of the economy of resources in heating systems of vehicles. To solve this problem we have developed an integrated method of research, which allows to solve tasks on optimization of parameters of ...
Andrei MELEKHIN, Aleksandr MELEKHIN
doaj  

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Process parameters optimization of EDM for hybrid aluminum MMC using hybrid optimization technique

Heliyon
This study explores how machining parameters affect Surface Roughness (SR), Tool Wear Rate (TWR), and Material Removal Rate (MRR) during Electrical Discharge Machining (EDM) of a hybrid aluminum metal matrix composite (AMMC).
Velusamy Mohankumar, Soorya Prakash Kumarasamy, Sivasubramanian Palanisamy, Ajith Kuriakose Mani, Thresh Kumar Durairaj, Mika Sillanpää, Saleh A. Al-Farraj   +6 more
doaj   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Optimization of thermal-flow behavior in porous TPMS cold plates via structural and numerical modeling

Engineering Applications of Computational Fluid Mechanics
Recently, biomimetic porous structures have garnered significant attention due to promising application in thermal management systems. However, flexible design and performance optimization remain challenges to the in-depth investigation of cold plate ...
Xi-Wei Tian, Zhuo-Lei Xue, Peng Li, Wei-Dong Wang, Si-Hao Qian, Chen Sun, Wen-Juan Suo, Wei Wang   +7 more
doaj   +1 more source

Multi-criterion parameters optimization of the heat exchanger element air heating system of a building

MATEC Web of Conferences, 2018
Air heating systems of buildings are resource-consuming systems, for this reason, improving their resource efficiency appears to be of great significance.
Melekhin Andrei
doaj   +1 more source

Two-Scale Topology Optimization with Isotropic and Orthotropic Microstructures

Designs, 2022
Advances in additive manufacturing enable the fabrication of complex structures with intricate geometric details, which bring opportunities for high-resolution structure design and transform the potential of functional product development.
Sina Rastegarzadeh, Jun Wang, Jida Huang
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source