Results 171 to 180 of about 217,541 (357)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Psychedelic minimalism: the case against music in psychedelic therapy settings. [PDF]

Front Psychiatry
Nader SA.
europepmc   +1 more source

Less is More: Perception as a fun way to Rich Minimalism. [PDF]

Iperception, 2022
Carbon CC, Utz S, Hesslinger VM.
europepmc   +1 more source

International Expert Consensus on Precision Anatomy for minimally invasive distal pancreatectomy: PAM‐HBP Surgery Project

, 2021
Daisuke Ban, Hitoe Nishino, Takao Ohtsuka, Yuichi Nagakawa, Mohammad Abu Hilal, Horacio J. Asbun, Ugo Boggi, Brian K. P. Goh, Jin He, Goro Honda, Jin‐Young Jang, Chang Moo Kang, Michael L. Kendrick, David A. Kooby, Rong Liu, Yoshiharu Nakamura, Kohei Nakata, Chinnusamy Palanivelu, Shailesh V. Shrikhande, Kyoichi Takaori, Chung‐Ngai Tang, Shin‐E Wang, Christopher L. Wolfgang, Anusak Yiengpruksawan, Yoo‐Seok Yoon, Rubén Ciria, Giammauro Berardi, Giovanni Maria Garbarino, Ryota Higuchi, Naoki Ikenaga, Yoshiya Ishikawa, Shingo Kozono, Aya Maekawa, Yoshiki Murase, Yusuke Watanabe, Giuseppe Zimmitti, F. Kunzler, Zizheng Wang, Leon Sakuma, Hiroaki Osakabe, Chie Takishita, Itaru Endo, Masao Tanaka, Hiroki Yamaue, Minoru Tanabe, Go Wakabayashi, Akihiko Tsuchida, Masafumi Nakamura   +47 more
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Ethics of Informed Consent for Data Registries: Moving Beyond Moral Minimalism to the High Ground. [PDF]

Bioethics
Chingarande GR.
europepmc   +1 more source

Innovations and Strategies During Online Teaching in an EdTech Low-Resourced University. [PDF]

SN Comput Sci, 2023
Lufungulo ES, Jia J, Mulubale S, Mambwe E, Mwila K.   +4 more
europepmc   +1 more source

Minimally invasive distal pancreatectomy: greatest benefit for the frail

, 2017
Ioannis T. Konstantinidis, Aaron Lewis, Byrne Lee, Susanne G. Warner, Yanghee Woo, Gagandeep Singh, Yuman Fong, Laleh G. Melstrom   +7 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

From simplicity to complexity: A path to innovation in science and art. [PDF]

Proc Natl Acad Sci U S A
Goldstein JL.
europepmc   +1 more source