Results 221 to 230 of about 2,396,405 (255)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Reduction of high-grade spondylolisthesis using minimally invasive spine surgery-transforaminal lumbar interbody fusion "trial-in-situ" technique: a technical note with case series. [PDF]

Asian Spine J
Kumar M, Rai V, Joshi A, Nalin S, Gandhi MK.   +4 more
europepmc   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Premium Intraocular Lens Selection in Patients With Glaucoma: A Clinical Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Glaucoma frequently coexists with cataract, but glaucomatous functional loss, ocular‐surface disease, anatomical abnormalities, and treatment‐related refractive variability may reduce tolerance of premium intraocular lenses. This narrative review critically appraises evidence relevant to lens selection in glaucoma. Central visual‐field status,
Zhihao Liu, Yajuan Zheng, Mingxuan Wang, Jing Zhao   +3 more
wiley   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source

3D‐Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair

Cell Proliferation, EarlyView.
3D printing transforms bioadhesives into structured, multifunctional interfaces that coordinate adhesion, mechanics, transport and biofunctional signalling and may thereby enable proliferative‐niche formation. Qualifying interfaces support cell survival, context‐appropriate proliferation and constructive remodelling advancing tissue repair towards ...
Zhen Gu, Xinyong Su, Guoshi Xu, Yongqiang Wen, Qi Gu   +4 more
wiley   +1 more source

Hammersmith Infant Neurological Examination global scores for predicting neurodevelopmental outcomes after 2 years of age: A systematic review and meta‐analysis

Developmental Medicine &Child Neurology, EarlyView.
Population: n = 21studies, 7299 infants Assessment: Hammersmith Infant Neurological Examination (HINE) Global Scores at 3 months (Corrected age), 6 months, 9 months, and 12 months. Crucial Finding: A HINE score <58 at 3 months predicts cerebral palsy (Sensitivity: 79.6%, Specificity: 88.7%).
Ting‐Ju Kuo, Hung‐Chou Chen, Yuan‐Hung Wang, Sung‐Hui Tseng   +3 more
wiley   +1 more source

Optimizing lie-to-stand time to avoid orthostatic intolerance during early mobilization after enhanced recovery after surgery program for minimally invasive spine surgery: oblique lateral interbody fusion versus minimally invasive transforaminal lumbar interbody fusion: a prospective cohort study in Thailand. [PDF]

Asian Spine J
Varakornpipat P, Kampitak W, Tanasansomboon T, Yingsakmongkol W, Limthongkul W, Kotheeranurak V, Mahatthanatrakul A, Singhatanadgige W.   +7 more
europepmc   +1 more source