Results 41 to 50 of about 2,956 (213)

Efficacy, safety and dose selection of AZD3759 in patients with untreated EGFR-mutated non-small-cell lung cancer and central nervous system metastases in China (CTONG1702-Arm 8): a multi-center, single-arm, phase 2 trialResearch in context

EClinicalMedicine, 2023
Summary: Background: Central nervous system (CNS) metastases is inevitable for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). AZD3759 is a novel EGFR-TKI with impressive CNS penetration.
Si-Yang Maggie Liu, Xiao-Rong Dong, Zhen Wang, Yingying Du, Jiu-Wei Cui, Qian Chu, Bing-Fei Xu, Ming-Ying Zheng, Jia-Yi Deng, Chang Lu, Xue-Wu Wei, Yang-Si Li, Mei-Mei Zheng, Ming-Yi Yang, Jie Huang, Anna Li, Xiao-Yan Bai, Yue-Li Sun, Chong-Rui Xu, Bin-Chao Wang, Hua-Jun Chen, Jin-Ji Yang, Hong-Hong Yan, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu   +25 more
doaj   +1 more source

Differential item functioning detection across multiple groups

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Differential item functioning (DIF) can be investigated by estimating item response theory (IRT) parameters separately for different respondent groups, thus allowing for the detection of discrepancies in parameter estimates across groups. However, before comparing the estimates, it is necessary to convert them to a common metric due to the ...
Michela Battauz
wiley   +1 more source

Accounting for grouped predictor variables or pathways in high-dimensional penalized Cox regression models

BMC Bioinformatics, 2020
Background The standard lasso penalty and its extensions are commonly used to develop a regularized regression model while selecting candidate predictor variables on a time-to-event outcome in high-dimensional data. However, these selection methods focus
Shaima Belhechmi, Riccardo De Bin, Federico Rotolo, Stefan Michiels   +3 more
doaj   +1 more source

Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine

BMC Bioinformatics, 2023
Background The research of biomarker-treatment interactions is commonly investigated in randomized clinical trials (RCT) for improving medicine precision. The hierarchical interaction constraint states that an interaction should only be in a model if its
Shaima Belhechmi, Gwénaël Le Teuff, Riccardo De Bin, Federico Rotolo, Stefan Michiels   +4 more
doaj   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

On invariant ideals in crossed products of torsion-free minimax nilpotent groups

Researches in Mathematics
Let $R$ be a finitely generated commutative domain and let $N$ be a nilpotent minimax torsion-free group acted by a solvable group of operators $G$ of finite rank.
A.V. Tushev
doaj   +1 more source

A Non‐Parametric Framework for Correlation Functions on Product Metric Spaces

International Statistical Review, EarlyView.
Summary We propose a non‐parametric framework for analysing data defined over products of metric spaces, a versatile class encountered in various fields. This framework accommodates non‐stationarity and seasonality and is applicable to both local and global domains, such as the Earth's surface, as well as domains evolving over linear time or time ...
Pier Giovanni Bissiri, Bernardo Nipoti, Emilio Porcu, Philip White   +3 more
wiley   +1 more source

Testing Distributional Granger Causality With Entropic Optimal Transport

Journal of Time Series Analysis, EarlyView.
ABSTRACT We develop a novel nonparametric test for Granger causality in distribution based on entropic optimal transport. Unlike classical mean‐based approaches, the proposed method directly compares the full conditional distributions of a response variable with and without the history of a candidate predictor.
Tao Wang
wiley   +1 more source

Machine learning approaches to characterize the obesogenic urban exposome

Environment International, 2022
Background: Characteristics of the urban environment may contain upstream drivers of obesity. However, research is lacking that considers the combination of environmental factors simultaneously.
Haykanush Ohanyan, Lützen Portengen, Anke Huss, Eugenio Traini, Joline W.J. Beulens, Gerard Hoek, Jeroen Lakerveld, Roel Vermeulen   +7 more
doaj   +1 more source

SMAA‐Based FITradeoff: An Efficient Framework for Pairwise Elicitation in Multicriteria Decision Analysis

Journal of Multi-Criteria Decision Analysis, Volume 33, Issue 2, August 2026.
ABSTRACT The Flexible and Interactive Tradeoff Elicitation (FITradeoff) method is a Multi‐Attribute Decision‐Making (MADM) approach designed to capture the preferences of a Decision Maker (DM) while minimising cognitive effort. To reduce the frequency of interactions and optimise the preference elicitation process, this paper introduces an innovative ...
Qian Zhao, Elia Balugani, Rita Gamberini, Francesco Lolli   +3 more
wiley   +1 more source