Results 31 to 40 of about 10,242 (124)
Exact Randomized Two‐Stage Phase 2 Clinical Trial Designs for Two Binary Co‐Primary Endpoints
Statistics in Medicine, Volume 45, Issue 3-5, February 2026.ABSTRACT Phase 2 clinical trials typically rely on a single primary endpoint, yet in many settings, treatment efficacy must be demonstrated across multiple co‐primary endpoints. Such settings require intersection‐union hypothesis testing, in which the global null hypothesis is rejected only when all individual component hypotheses are rejected ...
Hyejung Jung +3 more
wiley +1 more source
Recanting Twins: Addressing Intermediate Confounding in Mediation Analysis
Statistics in Medicine, Volume 45, Issue 3-5, February 2026.ABSTRACT The presence of intermediate confounders, also called recanting witnesses, is a fundamental challenge to the investigation of causal mechanisms in mediation analysis, preventing the identification of natural path‐specific effects. Common alternatives (such as randomizational interventional effects) are problematic because they can take non ...
Tat‐Thang Vo +4 more
wiley +1 more source
Wind Energy, Volume 29, Issue 2, February 2026.ABSTRACT This study presents a polynomial‐based wind speed profile characterization framework that approximates full vertical profiles using five physically meaningful Chebyshev polynomial coefficients. The framework captures key morphological features of wind profiles, including mean wind speed, vertical shear, curvature, inflection‐related behavior ...
Harish Baki, Sukanta Basu
wiley +1 more source
Minimax Structured Normal Means Inference
, 2016 We provide a unified treatment of a broad class of noisy structure recovery problems, known as structured normal means problems. In this setting, the goal is to identify, from a finite collection of Gaussian distributions with different means, the ...
Krishnamurthy, Akshay
core +1 more source
Movement Disorders, Volume 41, Issue 1, Page 190-199, January 2026.Abstract Background Disease‐modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two‐stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. Objective The aim was to assess the feasibility of Simon two‐stage futility trials in early, levodopa ...
Marcus W. Koch +12 more
wiley +1 more source
An Improved Bayesian Pick‐the‐Winner (IBPW) Design for Randomized Phase II Clinical Trials
Statistics in Medicine, Volume 45, Issue 1-2, January 2026.ABSTRACT Phase II clinical trials play a pivotal role in drug development by screening a large number of drug candidates to identify those with promising preliminary efficacy for phase III testing. Trial designs that enable efficient decision‐making with small sample sizes and early futility stopping while controlling for type I and type II errors in ...
Wanni Lei +3 more
wiley +1 more source
IET Smart Grid, Volume 9, Issue 1, January/December 2026.To support the ‘Dual Carbon’ strategy, this paper proposes a bilevel optimisation model for distributed energy storage configuration considering wind‐solar uncertainty and carbon trading. Using SNGAN and K‐means for scenario generation, the model minimises total cost at the upper level and grid vulnerability/power losses at the lower level.
Xiaonan Li +4 more
wiley +1 more source
Efficiency in Pure‐Exchange Economies With Risk‐Averse Monetary Utilities
Mathematical Finance, Volume 36, Issue 1, Page 99-117, January 2026.ABSTRACT We study Pareto efficiency in a pure‐exchange economy where agents' preferences are represented by risk‐averse monetary utilities. These coincide with law‐invariant monetary utilities, and they can be shown to correspond to the class of monotone, (quasi‐)concave, Schur concave, and translation‐invariant utility functionals. This covers a large
Mario Ghossoub, Michael B. Zhu
wiley +1 more source
Advanced Functional Materials, Volume 35, Issue 52, December 23, 2025.AI is transforming the research paradigm of battery materials and reshaping the entire landscape of battery technology. This comprehensive review summarizes the cutting‐edge applications of AI in the advancement of battery materials, underscores the critical challenges faced in harnessing the full potential of AI, and proposes strategic guidance for ...
Qingyun Hu +5 more
wiley +1 more source
Statistical Treatment Choice Based on Asymmetric Minimax Regret Criteria [PDF]
This paper studies the problem of treatment choice between a status quo treatment with a known outcome distribution and an innovation whose outcomes are observed only in a representative finite sample.
Aleksey Tetenov
core