Results 71 to 80 of about 213,568 (263)

Numerical analysis of minimum cost network flow with queuing stations: the M/M/1 case

open access: yesNova Scientia, 2017
En una red los nodos representan estaciones, almacenes, centros de distribución y c lientes y circulan tanto materiales como información, por lo que una herramienta utilizada para apoyar la toma de decisiones es el modelo de flujo a ...
Salvador Hernández-González   +3 more
doaj  

A New Method for Solving Single- and Multi-Objective Capacitated Solid Minimum Cost Flow Problems under Uncertainty

open access: yesJournal of Intelligent Systems, 2016
In real life, a person may assume that an object belongs to a set, but it is possible that he (she) is not sure about it. In other words, there may be hesitation or confusion whether an object belongs to a set or not.
Kaur Manjot, Sadiq Rehan
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

A Polynomial Combinatorial Algorithm for Generalized Minimum Cost Flow [PDF]

open access: yesMathematics of Operations Research, 1999
We propose the first combinatorial solution to the generalized minimum cost flow problem (flow with losses and gains). Despite a rich history dating back to Kantorovich and Dantzig, until now, the only known way to solve the problem in polynomial-time was via general-purpose linear programming techniques.
openaire   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

A Faster Strongly Polynomial Minimum Cost Flow Algorithm [PDF]

open access: yesOperations Research, 1988
In this paper, we present a new strongly polynomial time algorithm for the minimum cost flow problem, based on a refinement of the Edmonds-Karp scaling technique. Our algorithm solves the uncapacitated minimum cost flow problem as a sequence of O(n log n) shortest path problems on networks with n nodes and m arcs and runs in O(n log n(m + n log n ...
openaire   +4 more sources

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand   +5 more
wiley   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau   +11 more
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

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