Results 41 to 50 of about 218,505 (300)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Minimum Cost Flow Problem of Uncertain Random Network
, 2018 The aim of this paper is to present a novel method for solving the minimum cost flow problem on networks with uncertain-random capacities and costs.
Soheila Abdi +2 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Capacity Inverse Minimum Cost Flow Problem [PDF]
, 2007 Given a directed graph G = (N,A) with arc capacities u and a minimum cost flow problem defined on G, the capacity inverse minimum cost flow problem is to find a new capacity vector u' for the arc set A such that a given feasible flow x' is optimal with ...
Hamacher, Horst, Güler, Cigdem
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Faster Strongly Polynomial Minimum Cost Flow Algorithm
, 1988 We present a new strongly polynomial algorithm for the minimum cost flow problem, based on a refinement of the Edmonds-Karp scaling technique. Our algorithm solves the uncapacitated minimum cost flow problem as a sequence of O(n log n) shortest path ...
James B. Orlin, James Orlin
core +1 more source
Flow Increment through Network Expansion
Mathematics, 2021 The network expansion problem is a very important practical optimization problem when there is a need to increment the flow through an existing network of transportation, electricity, water, gas, etc.
Adrian Marius Deaconu, Luciana Majercsik
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Energies, 2021 The circulating cooling water system is widely used in various industrial production fields, and its operating cost largely depends on external factors, such as ambient temperature and working medium flow.
Peng Wang +4 more
doaj +1 more source