Results 91 to 100 of about 3,776,908 (250)

A Framework for Developing Biodiversity Conservation Networks Based on Morphological Spatial Pattern Analysis and the Maximum Entropy Model: A Case Study of the Jianghan Plain, China

Diversity
Constructing ecological networks in urban areas improves ecosystem stability and biodiversity protection. However, most studies focus on optimizing ecological environments through objective assessments, often neglecting species diversity.
Xiaohua Guo, Chang Liu, Shibo Bi, Xuewen Zhang   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Predictive Leakage Estimation using the Cumulative Minimum Night Flow Approach

, 2017
Several methods have been used in estimating leakages. Although the minimum night flow analysis method has been widely used in leakage estimation, the cumulative minimum night flow method is one method that can yield comparatively good leakage estimates.
Makaya Eugine
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A Basin-Scale Framework for Identifying Hydro-Cultural Heritage Corridor Patterns and Guiding Graded Protection: Evidence from the Xiangjiang River Basin, China

Land
Hydro-cultural heritage is shaped by strong hydrological dependence and historical accessibility. To address insufficient identification of river-basin heritage linkages and their weak translation into graded protection, this study develops an analytical
Yifan Wu, Sheng Jiao, Wenting Liu, Yan Yu, Kaiyin Xiao   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Statistical Modelling of Nonlinear Long-Term Cumulative Effects [PDF]

, 2010
In epidemiology, bio-environmental research, and many other scientific areas, the possible long-term cumulative effect of certain factors has been well acknowledged, air pollution on public health, exposure to radiation as a possible cause of cancer ...
Kong, Efang, Tong, Howell, Xia, Yingcun
core  

Spatial Construction and Optimization of Urban–Rural Heritage Corridors from the Perspective of Online Public Attention: A Case Study of Nanchang

Land
Urban–rural governance and planning systems, as viewed through the lens of online public attention, are reshaping approaches to achieving coordinated development of cultural heritage conservation and urban space.
Fen Xiao, Jingyi Guo, Yingying Feng, Shiqi Yang   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source