Results 141 to 150 of about 477,458 (300)

Verification and measurement of the side-cut angle of corneal flap in patients undergoing LASIK surgery using FS 200 kHz femtosecond laser system versus conventional mechanical microkeratome

Clinical Ophthalmology, 2019
Sarah Taha, Sarah Azzam, Mohamed Anis, Cherif Zaazou, Mohamed HosnyDepartment of Ophthalmology, Cairo University Hospital, Cairo, EgyptIntroduction: This is a prospective nonrandomized interventional clinical trial conducted to measure and verify the ...
Taha S, Azzam S, Anis M, Zaazou C, Hosny M   +4 more
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

GCphase: an SNP phasing method using a graph partition and error correction algorithm

BMC Bioinformatics
Background The utilization of long reads for single nucleotide polymorphism (SNP) phasing has become popular, providing substantial support for research on human diseases and genetic studies in animals and plants.
Junwei Luo, Jiayi Wang, Haixia Zhai, Junfeng Wang   +3 more
doaj   +1 more source

Multi-objective Optimization of End Milling Process Parameters for Minimum Surface Roughness Using MOGA

ITEGAM-JETIA
In this paper, a multi-objective genetic algorithm (MOGA) has been used for the optimization of end milling process parameters for minimum surface roughness and machining time.
Jignesh Girishbhai Parmar, Komal G. Dave, Mehul G. Mehta   +2 more
doaj   +1 more source

Performanace of Improved Minimum Spanning Tree Based on Clustering Technique

, 2012
Clustering technique is one of the most important and basic tool for data mining. Cluster algorithms have the ability to detect clusters with irregular boundaries, minimum spanning tree-based clustering algorithms have been widely used in practice.
Dr. P.Sampurnima
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Feasibility of using patient-specific models and the "minimum cut" algorithm to predict optimal ablation targets for left atrial flutter. [PDF]

Heart Rhythm, 2016
Zahid S, Whyte KN, Schwarz EL, Blake RC, Boyle PM, Chrispin J, Prakosa A, Ipek EG, Pashakhanloo F, Halperin HR, Calkins H, Berger RD, Nazarian S, Trayanova NA.   +13 more
europepmc   +1 more source

Proof that akers' algorithm for locally exhaustive testing gives minimum test sets of combinational circuits with up to four outputs

, 1993
In this paper, we prove that Akers' test generation algorithm for the locally exhaustive testing gives a minimum test set (MLTS) for every combinational circuit (CUT) with up to four outputs.
Okamoto, Takuji, H. Michinishi, Yokohira, Tokumi, T. Yokohira, T. Okamoto, Michinishi, Hiroyuki   +5 more
core   +1 more source