Results 151 to 160 of about 149,940 (277)

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Dietary outcomes of moderately wasted children treated in a food voucher program in Cameroon’s Far North: a three-month longitudinal study

BMC Nutrition
Background Many interventions in Cameroon focus on addressing severe wasting rather than targeting moderate wasting, although the latter is more prevalent.
Brice Ulrich Saha Foudjo, Ismael Teta, Jennifer Notkin Nielsen, Yunhee Kang, Georges Nguefack-Tsague, Carole Debora Nounkeu, Djeinam Touré, David Doledec, Julius Oben   +8 more
doaj   +1 more source

Is food insecurity more severe in South Asia or Sub-Saharan Africa?: A comparative analysis using household expenditure survey data [PDF]

"This paper uses data from national household expenditure surveys to explore whether food insecurity is more severe in South Asia or Sub-Saharan Africa.
Smith, Lisa C., Wiesmann, Doris
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Inadequate Dietary Diversity among Female Students in Southeast Sulawesi, Indonesia: Influences of Parental Education and Food Budget

Public Health of Indonesia
Introduction:Young people in Indonesia persistently grapple with nutritional challenges. Regrettably, there has been insufficient research addressing their distinct nutritional requirements.
Devi Savitri Effendy, Febriana Muchtar, Hartati Bahar, Nurmaladewi Nurmaladewi, Fifi Nirmala, Yustina Nurjanna   +5 more
doaj   +1 more source

Isotopic and genetic methods reveal the role of the gut microbiome in mammalian host essential amino acid metabolism. [PDF]

, 2020
Intestinal microbiota perform many functions for their host, but among the most important is their role in metabolism, especially the conversion of recalcitrant biomass that the host is unable to digest into bioavailable compounds.
Bradley, Christina J, Feeser, Kelli L, Fogel, Marilyn L, Newsome, Seth D, Takacs-Vesbach, Cristina, Wolf, Caitlin   +5 more
core   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

No. 08: International Migration and Urban Food Security in South African Cities [PDF]

, 2017
The drivers of food insecurity in rapidly growing urban areas of the Global South are receiving more research and policy attention, but the precise connections between urbanization, urban food security and migration are still largely unexplored.
Crush, Jonathan, Tawodzera, Godfrey
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source