Results 81 to 90 of about 149,940 (277)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Food consumption markers and minimum dietary diversity in different complementary feeding methods: a randomized clinical trial

DEMETRA: Alimentação, Nutrição & Saúde, 2023
Objective: To evaluate food consumption markers and minimum dietary diversity in 12-month-old infants exposed to different methods of food introduction. Methods: A randomized clinical trial with mother-infant pairs undergoing intervention on food introduction in three methods: Parent-Led Weaning (PLW), Baby-Led Introduction to SolidS (BLISS), and mixed
Paula Ruffoni Moreira, Leandro Meirelles Nunes, Bruna Oliveira de Vargas, Erissandra Gomes, Juliana Rombaldi Bernardi   +4 more
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Nutritional status, dietary diversity and morbidity among infants and children aged 6-23 months in rural Western Kenya [PDF]

, 2015
Poster presented at International Congress Of Tropical Paediatrics 2014.
Herrmann, J., Jordan, I., Keding, G.B., Krawinkel, M.B., Waswa L.M.   +4 more
core  

Analysis of the Effects of Dietary Pattern on the Oral Microbiome of Elite Endurance Athletes [PDF]

, 2019
Although the oral microbiota is known to play a crucial role in human health, there are few studies of diet x oral microbiota interactions, and none in elite athletes who may manipulate their intakes of macronutrients to achieve different metabolic ...
Burke, Louise M, Campbell, Katrina L, Charlesson, Bronwen, Krause, Lutz, Morrison, Mark, Murtaza, Nida, O'Neill, Hayley M, Ross, Megan L, Vlahovich, Nicole   +8 more
core   +3 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Effect of inappropriate complementary feeding practices on the nutritional status of children aged 6-24 months in urban Moshi, Northern Tanzania: Cohort study.

PLoS ONE, 2021
IntroductionChildhood undernutrition is a major public health problem especially in low and middle-income countries (LMIC). The prevalence of early introduction of complementary feeding, low meal frequency, and low dietary diversity are frequent in LMICs.
Rachel Masuke, Sia E Msuya, Johnson M Mahande, Ester J Diarz, Babill Stray-Pedersen, Ola Jahanpour, Melina Mgongo   +6 more
doaj   +1 more source

A comparative analysis of alternative food security indicators, using farm workers in the Northern Cape Province as a case study [PDF]

, 2019
Magister Artium (Development Studies) - MA(DVS)The concept of food insecurity is complex and difficult to measure. Food insecurity is measured at different levels – global, national, household and individual. In order to have appropriate assessments of
Devereux, Stephen, Ndondo, Zona
core  

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Family characteristics and non-food expenditure as determinants of dietary diversity among children aged 24–59 months in Karangkamulyan Village, Banten, Indonesia: A cross-sectional study [PDF]

Malaysian Family Physician
Introduction: Low dietary diversity is strongly associated with anaemia, stunting and underweight in young children. However, its determinants vary across populations.
Nabilah Alifia Firdauzy, Ratu Ayu Dewi Sartika   +1 more
doaj   +1 more source