Results 31 to 40 of about 5,404,126 (263)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Sensors, 2021 With the depletion of surface resources, mining will develop toward the deep surface in the future, the objective conditions such as the mining environment will be more complex and dangerous than now, and the requirements for personnel and equipment will
Haoxuan Yu +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Research on countermeasures of mining engineering talent training in the new situation
矿业科学学报, 2020 With Chinese comprehensive entry into the new era of socialism with Chinese characteristics stage of development, it is necessary to change the energy consumption structure to strengthen ecological civilization and social and economic development.As the ...
Yang Dapeng
doaj +1 more source
Research Progress of Mill Load Detection and Modeling Methods
Kuangchan zonghe liyong, 2023 This is a paper in the field of mining engineering. With the increasing demands for energy conservation and consumption reduction in mineral processing plants, ball mill load measurement is the key technology to realize mill control and optimize the ...
Ting Wang +4 more
doaj +1 more source
Mining association rules for the quality improvement of the production process [PDF]
, 2013 Academics and practitioners have a common interest in the continuing development of methods and computer applications that support or perform knowledge-intensive engineering tasks.
Rigal, Fabien +2 more
core +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Statistical overview of mining engineering education in Turkey
, 2022 In this study, the current situation of the Mining Engineering departments of the universities in Turkey was examined. In this context, first of all, general information about the Mining Engineering departments of the universities and the quota opened in
Kara, Tuğba Deniz Tombal +3 more
core +1 more source