Results 41 to 50 of about 218,332 (315)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Technology Progress and Development Trend of Preparing Magnesium Oxide from Magnesite
Kuangchan zonghe liyongThis is an article in the field of mining engineering. Magnesite in China is rich and good in quality. Its mineral quantity and grade rank the first in the world.
Yan HE +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ground engineering: principles and practices for underground coal mining [PDF]
, 2016 This book teaches readers ground engineering principles and related mining and risk management practices associated with underground coal mining. It establishes the basic elements of risk management and the fundamental principles of ground behaviour and ...
Galvin, J M
core +1 more source
Sensors, 2021 With the depletion of surface resources, mining will develop toward the deep surface in the future, the objective conditions such as the mining environment will be more complex and dangerous than now, and the requirements for personnel and equipment will
Haoxuan Yu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Research on countermeasures of mining engineering talent training in the new situation
矿业科学学报, 2020 With Chinese comprehensive entry into the new era of socialism with Chinese characteristics stage of development, it is necessary to change the energy consumption structure to strengthen ecological civilization and social and economic development.As the ...
Yang Dapeng
doaj +1 more source
Research Progress of Mill Load Detection and Modeling Methods
Kuangchan zonghe liyong, 2023 This is a paper in the field of mining engineering. With the increasing demands for energy conservation and consumption reduction in mineral processing plants, ball mill load measurement is the key technology to realize mill control and optimize the ...
Ting Wang +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source