Results 21 to 30 of about 109,617 (265)

Study of water-conducting fractured zone development law and assessment method in longwall mining of shallow coal seam

Scientific Reports, 2022
Starting from the source of mining, scientific understanding of surface damage law and assessment method in longwall mining of shallow coal seam is conducive to solving the problems of geological hazards and deterioration of the ecological environment ...
Xiaobin Li, Dongliang Ji, Penghua Han, Quansheng Li, Hongbao Zhao, Fulian He   +5 more
doaj   +1 more source

Geotechnical Engineering for Mass Mining

SEG Discovery, 2020
Editor’s note: The Geology and Mining series, edited by Dan Wood and Jeffrey Hedenquist, is designed to introduce early-career professionals and students to a variety of topics in mineral exploration, development, and mining, in order to provide insight into the many ways in which geoscientists contribute to the mineral industry.
openaire   +2 more sources

Exploration and practice in digital rock mechanics engineering

Meitan kexue jishu
Traditional mining engineering has long been trapped in the dilemma of “coexistence of mining operations and inherent risks”. The duality of its high-risk nature and resource contribution has become increasingly prominent under deep mining conditions. As
Hegang QI, Haitao LI, Jianwei ZHENG, Qingxin QI, Feng CAI, Baoyan ZHI, Guanchao MA, Jinguo WANG, Shanshan XUE, Haikuan ZHANG, Liang ZHANG, Chi LIU, YIqin LIU   +12 more
doaj   +1 more source

QUANTITATIVE ANALYSIS FOR MINING ENGINEERS. [PDF]

Journal of the American Chemical Society, 1904
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openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Engineering application and demonstration of intelligent mining control technology for rockburst coal seam

Meitan kexue jishu
How to achieve intelligent, safe and efficient mining of rockburst coal seams is a major engineering and technical challenge facing deep coal mining. The core connotation of this issue lies in the intelligent, unmanned, and inherently safe mining of coal
Hegang QI, Yongxue XIA, Baoyan ZHI, Zihan QIN, Jian CHENG, Kai WANG, Shuwen WANG, Binchang WANG, Guangyu YANG   +8 more
doaj   +1 more source

Combined support technology for main roadway passing through goaf: A case study

Energy Science & Engineering, 2020
Controlling the surrounding rock of the main roadway passing through a goaf during the reconstruction and expansion of a merger and reorganization mine is a common challenge in underground mining practices. In this study, a combined support technology of
Dongdong Chen, Qing Zhang, Shengrong Xie, Zaisheng Jiang, Yubo Li, Mingming Gao, Hui Li, Xiaoyu Wu, En Wang, Songhao Shi, Long Wang   +10 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Mathematical principle and engineering application of end-mining technology with non-pillar

Earth Energy Science
To ameliorate the difficulties of on-site dynamic disaster control in the end-mining stage of traditional mining engineering, this paper introduces the mathematical research and engineering application of the end-mining technology system with non-pillar ...
Jianyong Qiao, Zhiqiang Wang, Tingzhao Li, Yun Zhao   +3 more
doaj   +1 more source