Results 61 to 70 of about 281,089 (215)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Działalność duszpasterska o. dr. Władysława Siwka TJ w Szczecinie
Colloquia Theologica Ottoniana, 2013 Father dr Władysław Siwek (Society of Jesus) belongs to priests who signed up very clearly in the history of Szczecin and in the memory of its citizens. He worked in the city in the years 1950–1970 (with a break in the years 1955 to 1956, when the monks ...
Michał Siedziako
doaj
Mengelola Ekspektasi Jemaat terhadap Istri Gembala: Perspektif Expectancy Violations Theory
Dunamis: Jurnal Teologi dan Pendidikan Kristiani. The role of a pastor’s wife often comes with high congregational expectations, ranging from demands for perfection to full involvement in church ministry.
Esther Idayanti
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2022 Background: In recent decades, increasing productivity and reducing losses through the improvement of behavioral abnormalities at work has been considered by experts in organizational behavior, especially health researchers.
aaliyeh mirzaei +2 more
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Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
’n Begronde bedieningsmodel vir die diakonia van die gemeente
HTS Teologiese Studies/Theological Studies, 2012 A founded model for the ministry of the congregation’s diakonia. This article describes a founded model for ministry in the Reformed Church of Randburg (RCR) and the process that was followed to develop this model.
Gert Breed
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