Results 101 to 110 of about 245,216 (252)
Advanced Science, EarlyView.Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding +7 more
wiley +1 more source
Advanced Science, EarlyView.Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu +9 more
wiley +1 more source
«The Easter World» of Nicholas II during the Bell for Witte Tolled
Управленческое консультирование, 2018 Nicholas II tried to keep the state order existing at his father Alexander III, however the first years of his board were marked by acute shortage of activity of the government. Many years only the Ministry of Finance led by S.Yu.
Nelly Mikhailovna Tairova
doaj
Advanced Science, EarlyView.Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen +17 more
wiley +1 more source
Advanced Science, EarlyView.Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen +14 more
wiley +1 more source
Direct Observation of Vortex Liquid Droplets in the Iron Pnictide Superconductor CaKFe4As4 at 0.5Tc
Advanced Science, EarlyView.Vortex matter in the iron‐based superconductor CaKFe4As4${\rm CaKFe}_4{\rm As}_4$ is visualized at the nanoscale, revealing the unexpected emergence of vortex‐liquid droplets far below the critical temperature. These localized fluctuating regions coexist with a vortex solid, demonstrating that dissipation‐related dynamics arise well before macroscopic ...
Óscar Bou Marqués +9 more
wiley +1 more source
Advanced Science, EarlyView.A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An +8 more
wiley +1 more source
Formalizing digital health competencies for the health workforce in Ukraine. [PDF]
Front Public HealthZvinchuk O +4 more
europepmc +1 more source
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source
Correction: The role and future of the population health observatory: advancing public health intelligence in Saudi Arabia. [PDF]
Front Public HealthAl Eissa MM +8 more
europepmc +1 more source