Results 121 to 130 of about 245,216 (252)

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Tuberculosis preventive therapy in Sierra Leone: early implementation gaps and lessons learned. [PDF]

Public Health Action
Farma-Grant L, Kanu JS, Molleh B, Kamara IF, Kamara ARY, Sesay N, Lahai WK, Fofanah B, Falama MA, Offe Amponsah OK, Mahmoud M, Grant DS, Siatty Y, Zachariah R, Koroma J, Mustapha M, Sesay T, Kenneh S.   +17 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

The impact of US Government Stop Work Order on HIV epidemic trajectory in Zimbabwe. [PDF]

PLOS Glob Public Health
Taramusi I, Stover J, Feizzadeh A, Sithole N, Mpofu A, Apollo T, Mugurungi O, Madzima B, Makwanya L, Damisoni H, Makurumidze R, Rusakaniko S.   +11 more
europepmc   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

The Use of Tomographs in Brazil's National Health System: Case Study on the Efficiency of the Public Network in Rio Grande do Norte. [PDF]

Online J Public Health Inform
Barreto TO, de Oliveira Júnior EB, Dos Santos Felipe IJ, de Lima Paiva JC, Rodrigues Veras NV, de Macedo Silva L, Macedo da Costa JM, Santos de Aragão É, Góis Farias de Moura Santos Lima T, da Costa Barros C, Silveira E Silva R, Rocha de Andrade F, Holanda Cardoso P, Santos Pinheiro A, Medeiros Machado G, Miranda Veloso CM, Simões Camara Leão L, Dantas Coutinho K, de Medeiros Valentim RA.   +18 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

National Public Health Institutes in Africa, 2010-2025: pathways, governance, and outcomes, a scoping review. [PDF]

BMC Health Serv Res
Nyika H, Tiluhan T, Mugauri H.
europepmc   +1 more source

"Iye" and the Right of Househead in the "Deposition of Househead": An Analysis of the Judgements of Tokyo District Court and Administrative Orders of the Ministry of Public Affaires

Legal History Review, 2003
openaire   +2 more sources

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source