Results 41 to 50 of about 1,405,996 (300)

Agriculture and the River: The University's Role in Societal Learning, Innovation, and Action

Open Rivers, 2017
Rivers are critical connectors across our communities, states, and national boundaries. They offer essential benefits in the form of drinking water, recreation, transport, food, and aesthetics.
Nicholas R. Jordan, Carissa Schively Slotterback, David Mulla, and Len Kne
doaj   +1 more source

Navigating Indigenous Futures with the Mississippi River

Open Rivers, 2020
Relationalities, or the web of interconnected relations of kinship and ethical regard among Indigenous people, land, water, and sky scapes, include the agential or personhood status of otherwise non-human “natural” elements, their interconnectivity that ...
Vicente M. Diaz, Michael J. Dockry, G.-H. Crystal Ng, Virajita Singh, Daniel F. Keefe, Katie Johnston-Goodstar, Roxanne Biidabinokwe Gould, Jim Rock, and Christine Taitano DeLisle
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

One River: Telling Stories of the St. Louis River

Open Rivers, 2017
In fall 2016, some of the stories and legends of the St. Louis River were woven into a play called One River, written by theatre professor Tom Isbell and performed by a student cast from the University of Minnesota Duluth (UMD).
Phyllis Mauch Messenger
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The St. Louis River

Open Rivers, 2017
Within its relatively short length (194 miles) from its source to Lake Superior, and the truncated time frame of 300 years since European contact and colonization, the St.
Alex Messenger
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source