Results 41 to 50 of about 251,457 (257)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Agriculture and the River: The University's Role in Societal Learning, Innovation, and Action
Open Rivers, 2017 Rivers are critical connectors across our communities, states, and national boundaries. They offer essential benefits in the form of drinking water, recreation, transport, food, and aesthetics.
Nicholas R. Jordan, Carissa Schively Slotterback, David Mulla, and Len Kne
doaj +1 more source
Navigating Indigenous Futures with the Mississippi River
Open Rivers, 2020 Relationalities, or the web of interconnected relations of kinship and ethical regard among Indigenous people, land, water, and sky scapes, include the agential or personhood status of otherwise non-human “natural” elements, their interconnectivity that ...
Vicente M. Diaz, Michael J. Dockry, G.-H. Crystal Ng, Virajita Singh, Daniel F. Keefe, Katie Johnston-Goodstar, Roxanne Biidabinokwe Gould, Jim Rock, and Christine Taitano DeLisle
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
One River: Telling Stories of the St. Louis River
Open Rivers, 2017 In fall 2016, some of the stories and legends of the St. Louis River were woven into a play called One River, written by theatre professor Tom Isbell and performed by a student cast from the University of Minnesota Duluth (UMD).
Phyllis Mauch Messenger
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Open Rivers, 2017 Within its relatively short length (194 miles) from its source to Lake Superior, and the truncated time frame of 300 years since European contact and colonization, the St.
Alex Messenger
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source